3gi1

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[[Image:3gi1.png|left|200px]]
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==Crystal Structure of the laminin-binding protein Lbp of Streptococcus pyogenes==
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<StructureSection load='3gi1' size='340' side='right' caption='[[3gi1]], [[Resolution|resolution]] 2.45&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3gi1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptococcus_pyogenes Streptococcus pyogenes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GI1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3GI1 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">lmb, lmb/spy_2007 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1314 Streptococcus pyogenes])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3gi1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gi1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3gi1 RCSB], [http://www.ebi.ac.uk/pdbsum/3gi1 PDBsum]</span></td></tr>
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</table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gi/3gi1_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The common pathogen Streptococcus pyogenes colonizes the human skin and tonsils and can invade underlying tissues. This requires the adhesion of S. pyogenes to host surface receptors mediated through adhesins. The laminin-binding protein Lbp has been suggested as an adhesin, specific for the human extracellular matrix protein laminin. Sequence alignments, however, indicate a relationship between Lbp and a family of bacterial metal-binding receptors. To further analyze the role of Lbp in S. pyogenes and its potential role in pathogenicity, Lbp has been crystallized, and its structure has been solved at a resolution of 2.45 A (R = 0.186; R(free) = 0.251). Lbp has the typical metal-binding receptor fold, comprising two globular (beta/alpha)(4) domains connected by a helical backbone. The two domains enclose the metal-binding site, which contains a zinc ion. The interaction of Lbp with laminin was further investigated and shown to be specific in vitro. Localization studies with antibodies specific for Lbp show that the protein is attached to the membrane. The data suggest that Lbp is primarily a zinc-binding protein, and we suggest that its interaction with laminin in vivo may be mediated via zinc bound to laminin.
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{{STRUCTURE_3gi1| PDB=3gi1 | SCENE= }}
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The laminin-binding protein Lbp from Streptococcus pyogenes is a zinc receptor.,Linke C, Caradoc-Davies TT, Young PG, Proft T, Baker EN J Bacteriol. 2009 Sep;191(18):5814-23. Epub 2009 Jul 17. PMID:19617361<ref>PMID:19617361</ref>
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===Crystal Structure of the laminin-binding protein Lbp of Streptococcus pyogenes===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_19617361}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[3gi1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptococcus_pyogenes Streptococcus pyogenes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GI1 OCA].
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:019617361</ref><references group="xtra"/>
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[[Category: Streptococcus pyogenes]]
[[Category: Streptococcus pyogenes]]
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[[Category: Baker, E N.]]
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[[Category: Baker, E N]]
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[[Category: Caradoc-Davies, T T.]]
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[[Category: Caradoc-Davies, T T]]
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[[Category: Linke, C.]]
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[[Category: Linke, C]]
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[[Category: Proft, T.]]
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[[Category: Proft, T]]
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[[Category: Young, P G.]]
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[[Category: Young, P G]]
[[Category: Alpha/beta domain]]
[[Category: Alpha/beta domain]]
[[Category: Helical backbone]]
[[Category: Helical backbone]]

Revision as of 08:51, 8 December 2014

Crystal Structure of the laminin-binding protein Lbp of Streptococcus pyogenes

3gi1, resolution 2.45Å

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