2aph

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[[Image:2aph.gif|left|200px]]<br /><applet load="2aph" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:2aph.gif|left|200px]]
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caption="2aph, resolution 2.10&Aring;" />
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'''Crystal structure of human PGRP-IalphaC in complex with muramyl pentapeptide'''<br />
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{{Structure
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|PDB= 2aph |SIZE=350|CAPTION= <scene name='initialview01'>2aph</scene>, resolution 2.10&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene> and <scene name='pdbligand=NH2:AMINO GROUP'>NH2</scene>
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|ACTIVITY=
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|GENE= PGLYRP3, PGRPIA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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}}
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'''Crystal structure of human PGRP-IalphaC in complex with muramyl pentapeptide'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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2APH is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=SO4:'>SO4</scene> and <scene name='pdbligand=NH2:'>NH2</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2APH OCA].
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2APH is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2APH OCA].
==Reference==
==Reference==
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Crystal structure of human peptidoglycan recognition protein I alpha bound to a muramyl pentapeptide from Gram-positive bacteria., Guan R, Brown PH, Swaminathan CP, Roychowdhury A, Boons GJ, Mariuzza RA, Protein Sci. 2006 May;15(5):1199-206. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16641493 16641493]
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Crystal structure of human peptidoglycan recognition protein I alpha bound to a muramyl pentapeptide from Gram-positive bacteria., Guan R, Brown PH, Swaminathan CP, Roychowdhury A, Boons GJ, Mariuzza RA, Protein Sci. 2006 May;15(5):1199-206. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16641493 16641493]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: lys-type]]
[[Category: lys-type]]
[[Category: peptidoglycan]]
[[Category: peptidoglycan]]
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[[Category: pgrps]]
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[[Category: pgrp]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:29:40 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:52:18 2008''

Revision as of 13:52, 20 March 2008

Image:2aph.gif


PDB ID 2aph

Drag the structure with the mouse to rotate
, resolution 2.10Å
Ligands: and
Gene: PGLYRP3, PGRPIA (Homo sapiens)
Coordinates: save as pdb, mmCIF, xml



Crystal structure of human PGRP-IalphaC in complex with muramyl pentapeptide


Overview

Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors of the innate immune system that bind bacterial peptidoglycans (PGNs). We determined the crystal structure, to 2.1 A resolution, of the C-terminal PGN-binding domain of human PGRP-I alpha in complex with a muramyl pentapeptide (MPP) from Gram-positive bacteria containing a complete peptide stem (L-Ala-D-isoGln-L-Lys-D-Ala-D-Ala). The structure reveals important features not observed previously in the complex between PGRP-I alpha and a muramyl tripeptide lacking D-Ala at stem positions 4 and 5. Most notable are ligand-induced structural rearrangements in the PGN-binding site that are essential for entry of the C-terminal portion of the peptide stem and for locking MPP in the binding groove. We propose that similar structural rearrangements to accommodate the PGN stem likely characterize many PGRPs, both mammalian and insect.

About this Structure

2APH is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of human peptidoglycan recognition protein I alpha bound to a muramyl pentapeptide from Gram-positive bacteria., Guan R, Brown PH, Swaminathan CP, Roychowdhury A, Boons GJ, Mariuzza RA, Protein Sci. 2006 May;15(5):1199-206. PMID:16641493

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