3h15

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m (Protected "3h15" [edit=sysop:move=sysop])
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[[Image:3h15.png|left|200px]]
 
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{{STRUCTURE_3h15| PDB=3h15 | SCENE= }}
{{STRUCTURE_3h15| PDB=3h15 | SCENE= }}
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===Crystal structure of replication initiation factor MCM10-ID bound to ssDNA===
===Crystal structure of replication initiation factor MCM10-ID bound to ssDNA===
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{{ABSTRACT_PUBMED_19608746}}
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{{ABSTRACT_PUBMED_19608746}}
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==Function==
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[[http://www.uniprot.org/uniprot/MCM10_XENLA MCM10_XENLA]] Acts as a replication initiation factor that brings together the MCM2-7 helicase and the DNA polymerase alpha/primase complex in order to initiate DNA replication. Additionally, plays a role in preventing DNA damage during replication (By similarity).<ref>PMID:11864598</ref>
==About this Structure==
==About this Structure==
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==Reference==
==Reference==
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<ref group="xtra">PMID:019608746</ref><references group="xtra"/>
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<ref group="xtra">PMID:019608746</ref><references group="xtra"/><references/>
[[Category: Xenopus laevis]]
[[Category: Xenopus laevis]]
[[Category: Eichman, B F.]]
[[Category: Eichman, B F.]]

Revision as of 06:58, 29 September 2013

Template:STRUCTURE 3h15

Contents

Crystal structure of replication initiation factor MCM10-ID bound to ssDNA

Template:ABSTRACT PUBMED 19608746

Function

[MCM10_XENLA] Acts as a replication initiation factor that brings together the MCM2-7 helicase and the DNA polymerase alpha/primase complex in order to initiate DNA replication. Additionally, plays a role in preventing DNA damage during replication (By similarity).[1]

About this Structure

3h15 is a 2 chain structure with sequence from Xenopus laevis. Full crystallographic information is available from OCA.

Reference

  • Warren EM, Huang H, Fanning E, Chazin WJ, Eichman BF. Physical interactions between Mcm10, DNA, and DNA polymerase alpha. J Biol Chem. 2009 Sep 4;284(36):24662-72. Epub 2009 Jul 16. PMID:19608746 doi:10.1074/jbc.M109.020438
  1. ↑ Wohlschlegel JA, Dhar SK, Prokhorova TA, Dutta A, Walter JC. Xenopus Mcm10 binds to origins of DNA replication after Mcm2-7 and stimulates origin binding of Cdc45. Mol Cell. 2002 Feb;9(2):233-40. PMID:11864598

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OCA

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