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4hv3

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[[Image:4hv3.png|left|200px]]
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==Structure of Ricin A chain bound with N-(N-(pterin-7-yl)carbonyl-L-serinyl)-L-tryptophan==
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<StructureSection load='4hv3' size='340' side='right' caption='[[4hv3]], [[Resolution|resolution]] 1.54&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4hv3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Ricinus_communis Ricinus communis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HV3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HV3 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=19L:(2S)-2-[[(2S)-2-[(2-AZANYL-4-OXIDANYLIDENE-1H-PTERIDIN-7-YL)CARBONYLAMINO]-3-OXIDANYL-PROPANOYL]AMINO]-3-(1H-INDOL-3-YL)PROPANOIC+ACID'>19L</scene>, <scene name='pdbligand=MLA:MALONIC+ACID'>MLA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1rtc|1rtc]], [[1ift|1ift]], [[1br6|1br6]], [[1px8|1px8]], [[1px9|1px9]], [[4esi|4esi]], [[4huo|4huo]], [[4hup|4hup]], [[4hv7|4hv7]]</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/rRNA_N-glycosylase rRNA N-glycosylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.22 3.2.2.22] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hv3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hv3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4hv3 RCSB], [http://www.ebi.ac.uk/pdbsum/4hv3 PDBsum]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Several 7-peptide-substituted pterins were synthesized and tested as competitive active-site inhibitors of ricin toxin A (RTA). Focus began on dipeptide conjugates, and these results further guided the construction of several tripeptide conjugates. The binding of these compounds to RTA was studied via a luminescence-based kinetic assay, as well as through X-ray crystallography. Despite the relatively polar, solvent exposed active site, several hydrophobic interactions, most commonly pi-interactions not predicted by modeling programs, were identified in all of the best-performing inhibitors. Nearly all of these compounds provide IC(50) values in the low micromolar range.
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{{STRUCTURE_4hv3| PDB=4hv3 | SCENE= }}
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Peptide-Conjugated Pterins as Inhibitors of Ricin Toxin A.,Saito R, Pruet JM, Manzano LA, Jasheway K, Monzingo AF, Wiget PA, Kamat I, Anslyn EV, Robertus JD J Med Chem. 2012 Dec 19. PMID:23214944<ref>PMID:23214944</ref>
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===Structure of Ricin A chain bound with N-(N-(pterin-7-yl)carbonyl-L-serinyl)-L-tryptophan===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_23214944}}
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==See Also==
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*[[Ricin|Ricin]]
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==About this Structure==
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== References ==
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[[4hv3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Ricinus_communis Ricinus communis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HV3 OCA].
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<references/>
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__TOC__
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</StructureSection>
[[Category: Ricinus communis]]
[[Category: Ricinus communis]]
[[Category: RRNA N-glycosylase]]
[[Category: RRNA N-glycosylase]]
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[[Category: Anslyn, E V.]]
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[[Category: Anslyn, E V]]
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[[Category: Jasheway, K R.]]
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[[Category: Jasheway, K R]]
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[[Category: Manzano, L A.]]
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[[Category: Manzano, L A]]
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[[Category: Monzingo, A F.]]
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[[Category: Monzingo, A F]]
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[[Category: Pruet, J M.]]
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[[Category: Pruet, J M]]
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[[Category: Robertus, J D.]]
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[[Category: Robertus, J D]]
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[[Category: Saito, R.]]
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[[Category: Saito, R]]
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[[Category: Wiget, P A.]]
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[[Category: Wiget, P A]]
[[Category: Hydrolase]]
[[Category: Hydrolase]]
[[Category: Hydrolase-hydrolase inhibitor complex]]
[[Category: Hydrolase-hydrolase inhibitor complex]]

Revision as of 09:42, 10 December 2014

Structure of Ricin A chain bound with N-(N-(pterin-7-yl)carbonyl-L-serinyl)-L-tryptophan

4hv3, resolution 1.54Å

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