4i7f
From Proteopedia
(Difference between revisions)
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| - | [[ | + | ==HIV-1 Reverse Transcriptase in complex with a phosphonate analog of nevirapine== |
| + | <StructureSection load='4i7f' size='340' side='right' caption='[[4i7f]], [[Resolution|resolution]] 2.50Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4i7f]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Hiv-1_m:b_hxb2r Hiv-1 m:b_hxb2r]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I7F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4I7F FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NVE:DIETHYL+({4-[2-(11-ETHYL-5-METHYL-6-OXO-6,11-DIHYDRO-5H-DIPYRIDO[3,2-B 2,3-E][1,4]DIAZEPIN-8-YL)ETHYL]PHENOXY}METHYL)PHOSPHONATE'>NVE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">gag-pol, reverse transcriptase ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11706 HIV-1 M:B_HXB2R])</td></tr> | ||
| + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/RNA-directed_DNA_polymerase RNA-directed DNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.49 2.7.7.49] </span></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4i7f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4i7f OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4i7f RCSB], [http://www.ebi.ac.uk/pdbsum/4i7f PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | A series of nevirapine-based analogues containing the phosphonate functionality were prepared and evaluated in vitro against HIV RT. The effect of the phosphonate was evaluated against the wild type and Y181C HIV replication. An in vivo PK study was performed on a select analogue. | ||
| - | + | Synthesis and biological evaluation of phosphonate analogues of nevirapine.,Parrish J, Tong L, Wang M, Chen X, Lansdon EB, Cannizzaro C, Zheng X, Desai MC, Xu L Bioorg Med Chem Lett. 2013 Mar 1;23(5):1493-7. doi: 10.1016/j.bmcl.2012.12.049., Epub 2012 Dec 21. PMID:23375792<ref>PMID:23375792</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| + | </div> | ||
| - | + | ==See Also== | |
| - | + | *[[Reverse transcriptase|Reverse transcriptase]] | |
| - | == | + | == References == |
| - | [[ | + | <references/> |
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Hiv-1 m:b_hxb2r]] | [[Category: Hiv-1 m:b_hxb2r]] | ||
[[Category: RNA-directed DNA polymerase]] | [[Category: RNA-directed DNA polymerase]] | ||
| - | [[Category: Lansdon, E B | + | [[Category: Lansdon, E B]] |
| - | [[Category: Parrish, J | + | [[Category: Parrish, J]] |
[[Category: Hiv]] | [[Category: Hiv]] | ||
[[Category: Hydrolase-hydrolase inhibitor complex]] | [[Category: Hydrolase-hydrolase inhibitor complex]] | ||
[[Category: Nnrti]] | [[Category: Nnrti]] | ||
[[Category: Reverse transcriptase]] | [[Category: Reverse transcriptase]] | ||
Revision as of 17:04, 10 December 2014
HIV-1 Reverse Transcriptase in complex with a phosphonate analog of nevirapine
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