3w1f

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'''Unreleased structure'''
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{{STRUCTURE_3w1f| PDB=3w1f | SCENE= }}
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===Crystal structure of Human MPS1 catalytic domain in complex with 5-(5-ethoxy-6-(1-methyl-1H-pyrazol-4-yl)-1H-indazol-3-yl)-2-methylbenzenesulfonamide===
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{{ABSTRACT_PUBMED_23634759}}
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The entry 3w1f is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/TTK_HUMAN TTK_HUMAN]] Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation. Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint.<ref>PMID:18243099</ref>
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Authors: Kusakabe, K., Ide, N., Daigo, Y., Tachibana, Y., Itoh, T., Yamamoto, T., Hashizume, H., Hato, Y., Higashino, K., Okano, Y., Sato, Y., Inoue, M., Iguchi, M., Kanazawa, T., Ishioka, Y., Dohi, K., Kido, Y., Sakamoto, S., Yasuo, K., Maeda, M., Higaki, M., Ueda, K., Yoshizawa, H., Baba, Y., Shiota, T., Murai, H., Nakamura, Y.
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==About this Structure==
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[[3w1f]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3W1F OCA].
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Description: CRYSTAL STRUCTURE OF HUMAN MPS1 CATALYTIC DOMAIN IN COMPLEX WITH 5-(5-ethoxy-6-(1-methyl-1H-pyrazol-4-yl)-1H-indazol-3-yl)-2-methylbenzenesulfonamide
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==Reference==
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<ref group="xtra">PMID:023634759</ref><references group="xtra"/><references/>
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[[Category: Dual-specificity kinase]]
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[[Category: Homo sapiens]]
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[[Category: Baba, Y.]]
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[[Category: Daigo, Y.]]
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[[Category: Dohi, K.]]
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[[Category: Hashizume, H.]]
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[[Category: Hato, Y.]]
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[[Category: Higaki, M.]]
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[[Category: Higashino, K.]]
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[[Category: Ide, N.]]
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[[Category: Iguchi, M.]]
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[[Category: Inoue, M.]]
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[[Category: Ishioka, Y.]]
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[[Category: Itoh, T.]]
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[[Category: Kanazawa, T.]]
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[[Category: Kido, Y.]]
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[[Category: Kusakabe, K.]]
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[[Category: Maeda, M.]]
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[[Category: Murai, H.]]
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[[Category: Nakamura, Y.]]
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[[Category: Okano, Y.]]
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[[Category: Sakamoto, S.]]
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[[Category: Sato, Y.]]
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[[Category: Shiota, T.]]
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[[Category: Tachibana, Y.]]
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[[Category: Ueda, K.]]
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[[Category: Yamamoto, T.]]
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[[Category: Yasuo, K.]]
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[[Category: Yoshizawa, H.]]
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[[Category: Kinase]]
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[[Category: Serine/threonine-protein kinase]]
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[[Category: Transferase-transferase inhibitor complex]]

Revision as of 10:13, 30 June 2013

Template:STRUCTURE 3w1f

Contents

Crystal structure of Human MPS1 catalytic domain in complex with 5-(5-ethoxy-6-(1-methyl-1H-pyrazol-4-yl)-1H-indazol-3-yl)-2-methylbenzenesulfonamide

Template:ABSTRACT PUBMED 23634759

Function

[TTK_HUMAN] Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation. Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint.[1]

About this Structure

3w1f is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Kusakabe K, Ide N, Daigo Y, Tachibana Y, Itoh T, Yamamoto T, Hashizume H, Hato Y, Higashino K, Okano Y, Sato Y, Inoue M, Iguchi M, Kanazawa T, Ishioka Y, Dohi K, Kido Y, Sakamoto S, Yasuo K, Maeda M, Higaki M, Ueda K, Yoshizawa H, Baba Y, Shiota T, Murai H, Nakamura Y. Indazole-Based Potent and Cell-Active Mps1 Kinase Inhibitors: Rational Design from Pan-Kinase Inhibitor Anthrapyrazolone (SP600125). J Med Chem. 2013 Jun 13;56(11):4343-56. doi: 10.1021/jm4000215. Epub 2013 May 24. PMID:23634759 doi:10.1021/jm4000215
  1. ↑ Jelluma N, Brenkman AB, van den Broek NJ, Cruijsen CW, van Osch MH, Lens SM, Medema RH, Kops GJ. Mps1 phosphorylates Borealin to control Aurora B activity and chromosome alignment. Cell. 2008 Jan 25;132(2):233-46. doi: 10.1016/j.cell.2007.11.046. PMID:18243099 doi:10.1016/j.cell.2007.11.046

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