2ate

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[[Image:2ate.gif|left|200px]]<br /><applet load="2ate" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:2ate.gif|left|200px]]
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caption="2ate, resolution 1.80&Aring;" />
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'''Structure of the complex of PurE with NitroAIR'''<br />
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{{Structure
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|PDB= 2ate |SIZE=350|CAPTION= <scene name='initialview01'>2ate</scene>, resolution 1.80&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=NIA:((2R,3S,4R,5R)-5-(5-AMINO-4-NITRO-1H-IMIDAZOL-1-YL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL)METHYL DIHYDROGEN PHOSPHATE'>NIA</scene>
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|ACTIVITY= [http://en.wikipedia.org/wiki/Phosphoribosylaminoimidazole_carboxylase Phosphoribosylaminoimidazole carboxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.21 4.1.1.21]
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|GENE= purE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])
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}}
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'''Structure of the complex of PurE with NitroAIR'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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2ATE is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with <scene name='pdbligand=NIA:'>NIA</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Phosphoribosylaminoimidazole_carboxylase Phosphoribosylaminoimidazole carboxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.21 4.1.1.21] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ATE OCA].
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2ATE is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ATE OCA].
==Reference==
==Reference==
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Modular evolution of the purine biosynthetic pathway., Kappock TJ, Ealick SE, Stubbe J, Curr Opin Chem Biol. 2000 Oct;4(5):567-72. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11006546 11006546]
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Modular evolution of the purine biosynthetic pathway., Kappock TJ, Ealick SE, Stubbe J, Curr Opin Chem Biol. 2000 Oct;4(5):567-72. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11006546 11006546]
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Phosphoribosylaminoimidazole carboxylase]]
[[Category: Phosphoribosylaminoimidazole carboxylase]]
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[[Category: pure]]
[[Category: pure]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:30:51 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:53:39 2008''

Revision as of 13:53, 20 March 2008

Image:2ate.gif


PDB ID 2ate

Drag the structure with the mouse to rotate
, resolution 1.80Å
Ligands:
Gene: purE (Escherichia coli)
Activity: Phosphoribosylaminoimidazole carboxylase, with EC number 4.1.1.21
Coordinates: save as pdb, mmCIF, xml



Structure of the complex of PurE with NitroAIR


Overview

Structural studies, sequence alignments, and biochemistry have provided new insights into the evolution of the purine biosynthetic pathway. The importance of chemistry, the binding of ribose 5-phosphate (common to all purine biosynthetic intermediates), and transient protein-protein interactions in channeling of chemically unstable intermediates have all been examined in the past few years.

About this Structure

2ATE is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Modular evolution of the purine biosynthetic pathway., Kappock TJ, Ealick SE, Stubbe J, Curr Opin Chem Biol. 2000 Oct;4(5):567-72. PMID:11006546

Page seeded by OCA on Thu Mar 20 15:53:39 2008

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