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4jbj

From Proteopedia

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'''Unreleased structure'''
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{{STRUCTURE_4jbj| PDB=4jbj | SCENE= }}
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===Structural mimicry for functional antagonism===
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The entry 4jbj is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/IFI2_MOUSE IFI2_MOUSE]] Inhibits the transcriptional activity of several transcription factors, including NF-kappa-B p50 and p65, FOS, JUN, E2F1, E2F4, MYOD1 and myogenin. Has anti-apoptotic effects due to inhibition of the transcriptional activity of p53. Binds dsDNA in the cytosol. Is involved in innate immune response and has anti-inflammatory activity. Inhibits caspase activation in response to cytosolic DNA and may inhibit the activation of the AIM2 inflammasome, probably via association with AIM2.<ref>PMID:16670293</ref> <ref>PMID:19131592</ref>
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Authors: Ru, H., Ni, X.-M., Ma, F., Zhao, L.-X., Ding, W., Hung, L.-W., Shaw, N., Cheng, G.-H., Liu, Z.-J.
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==About this Structure==
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[[4jbj]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JBJ OCA].
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Description: Structural mimicry for functional antagonism
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==Reference==
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<ref group="xtra">PMID:023567559</ref><references group="xtra"/><references/>
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[[Category: Mus musculus]]
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[[Category: Cheng, G.]]
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[[Category: Ding, W.]]
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[[Category: Hung, L W.]]
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[[Category: Liu, Z J.]]
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[[Category: Ma, F.]]
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[[Category: Ni, X.]]
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[[Category: Ru, H.]]
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[[Category: Shaw, N.]]
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[[Category: Zhao, L.]]
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[[Category: Dna binding protein]]
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[[Category: Ds dna]]
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[[Category: Ob fold]]

Revision as of 09:55, 30 June 2013

Template:STRUCTURE 4jbj

Contents

Structural mimicry for functional antagonism

Function

[IFI2_MOUSE] Inhibits the transcriptional activity of several transcription factors, including NF-kappa-B p50 and p65, FOS, JUN, E2F1, E2F4, MYOD1 and myogenin. Has anti-apoptotic effects due to inhibition of the transcriptional activity of p53. Binds dsDNA in the cytosol. Is involved in innate immune response and has anti-inflammatory activity. Inhibits caspase activation in response to cytosolic DNA and may inhibit the activation of the AIM2 inflammasome, probably via association with AIM2.[1] [2]

About this Structure

4jbj is a 2 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

  • Ru H, Ni X, Zhao L, Crowley C, Ding W, Hung LW, Shaw N, Cheng G, Liu ZJ. Structural basis for termination of AIM2-mediated signaling by p202. Cell Res. 2013 Jun;23(6):855-8. doi: 10.1038/cr.2013.52. Epub 2013 Apr 9. PMID:23567559 doi:10.1038/cr.2013.52
  1. ↑ Xin H, D'Souza S, Jorgensen TN, Vaughan AT, Lengyel P, Kotzin BL, Choubey D. Increased expression of Ifi202, an IFN-activatable gene, in B6.Nba2 lupus susceptible mice inhibits p53-mediated apoptosis. J Immunol. 2006 May 15;176(10):5863-70. PMID:16670293
  2. ↑ Roberts TL, Idris A, Dunn JA, Kelly GM, Burnton CM, Hodgson S, Hardy LL, Garceau V, Sweet MJ, Ross IL, Hume DA, Stacey KJ. HIN-200 proteins regulate caspase activation in response to foreign cytoplasmic DNA. Science. 2009 Feb 20;323(5917):1057-60. doi: 10.1126/science.1169841. Epub 2009, Jan 8. PMID:19131592 doi:10.1126/science.1169841

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