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3j2u

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[[Image:3j2u.jpg|left|200px]]
 
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{{STRUCTURE_3j2u| PDB=3j2u | SCENE= }}
{{STRUCTURE_3j2u| PDB=3j2u | SCENE= }}
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===Kinesin-13 KLP10A HD in complex with CS-tubulin and a microtubule===
===Kinesin-13 KLP10A HD in complex with CS-tubulin and a microtubule===
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{{ABSTRACT_PUBMED_23434508}}
{{ABSTRACT_PUBMED_23434508}}
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==Function==
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[[http://www.uniprot.org/uniprot/KI10A_DROME KI10A_DROME]] Required during anaphase to drive sister chromatid separation to promote flux by actively depolymerizing kinetochore microtubules at their pole-associated minus ends, thereby moving chromatids through a "poleward flux".<ref>PMID:14681690</ref> [[http://www.uniprot.org/uniprot/TBB2B_BOVIN TBB2B_BOVIN]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity). [[http://www.uniprot.org/uniprot/TBA1B_BOVIN TBA1B_BOVIN]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.
==About this Structure==
==About this Structure==
[[3j2u]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [http://en.wikipedia.org/wiki/Gekko_coi Gekko coi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3J2U OCA].
[[3j2u]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [http://en.wikipedia.org/wiki/Gekko_coi Gekko coi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3J2U OCA].
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==Reference==
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<references group="xtra"/><references/>
[[Category: Bos taurus]]
[[Category: Bos taurus]]
[[Category: Gekko coi]]
[[Category: Gekko coi]]

Revision as of 21:57, 10 April 2013

Template:STRUCTURE 3j2u

Contents

Kinesin-13 KLP10A HD in complex with CS-tubulin and a microtubule

Template:ABSTRACT PUBMED 23434508

Function

[KI10A_DROME] Required during anaphase to drive sister chromatid separation to promote flux by actively depolymerizing kinetochore microtubules at their pole-associated minus ends, thereby moving chromatids through a "poleward flux".[1] [TBB2B_BOVIN] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity). [TBA1B_BOVIN] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.

About this Structure

3j2u is a 5 chain structure with sequence from Bos taurus and Gekko coi. Full crystallographic information is available from OCA.

Reference

  1. ↑ Rogers GC, Rogers SL, Schwimmer TA, Ems-McClung SC, Walczak CE, Vale RD, Scholey JM, Sharp DJ. Two mitotic kinesins cooperate to drive sister chromatid separation during anaphase. Nature. 2004 Jan 22;427(6972):364-70. Epub 2003 Dec 14. PMID:14681690 doi:10.1038/nature02256

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