3zp5
From Proteopedia
(Difference between revisions)
m (Protected "3zp5" [edit=sysop:move=sysop]) |
|||
| Line 1: | Line 1: | ||
| - | + | ==Crystal structure of the DNA binding ETS domain of the human protein FEV in complex with DNA== | |
| - | + | <StructureSection load='3zp5' size='340' side='right' caption='[[3zp5]], [[Resolution|resolution]] 2.00Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[3zp5]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZP5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZP5 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zp5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zp5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zp5 RCSB], [http://www.ebi.ac.uk/pdbsum/3zp5 PDBsum]</span></td></tr> | |
| - | + | </table> | |
| - | + | == Disease == | |
| - | == | + | [[http://www.uniprot.org/uniprot/FEV_HUMAN FEV_HUMAN]] Disease susceptibility may be associated with variations affecting the gene represented in this entry. A chromosomal aberration involving FEV is found in Ewing tumors. Translocation t(2;21;22)(q23;q22;q12) that forms a EWSR1-FEV fusion protein with a potential oncogenic activity. |
| - | [[3zp5]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZP5 OCA]. | + | == Function == |
| + | [[http://www.uniprot.org/uniprot/FEV_HUMAN FEV_HUMAN]] Functions as a transcriptional regulator. According to PubMed:12761502, it functions as a transcriptional repressor. Functions in the differentiation and the maintenance of the central serotonergic neurons. May play a role in cell growth.<ref>PMID:12761502</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Allerston, C K | + | [[Category: Allerston, C K]] |
| - | [[Category: Arrowsmith, C H | + | [[Category: Arrowsmith, C H]] |
| - | [[Category: Burgess-Brown, N | + | [[Category: Burgess-Brown, N]] |
| - | [[Category: Cooper, C D.O | + | [[Category: Cooper, C D.O]] |
| - | [[Category: Delft, F von | + | [[Category: Delft, F von]] |
| - | [[Category: Edwards, A | + | [[Category: Edwards, A]] |
| - | [[Category: Gileadi, O | + | [[Category: Gileadi, O]] |
| - | [[Category: Krojer, T | + | [[Category: Krojer, T]] |
| - | [[Category: Newman, J A | + | [[Category: Newman, J A]] |
| - | [[Category: Shrestha, L | + | [[Category: Shrestha, L]] |
| - | [[Category: Vollmar, M | + | [[Category: Vollmar, M]] |
[[Category: Transcription-dna complex]] | [[Category: Transcription-dna complex]] | ||
Revision as of 16:06, 9 December 2014
Crystal structure of the DNA binding ETS domain of the human protein FEV in complex with DNA
| |||||||||||
