4ajg

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[[Image:4ajg.jpg|left|200px]]
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==Identification and structural characterization of PDE10 fragment inhibitors==
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<StructureSection load='4ajg' size='340' side='right' caption='[[4ajg]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4ajg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AJG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AJG FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=F07:THIENO[3,2-C][1,6]NAPHTHYRIDINE'>F07</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1lrb|1lrb]], [[2wey|2wey]], [[2y0j|2y0j]], [[4ael|4ael]], [[4ajd|4ajd]], [[4ajf|4ajf]], [[4ajm|4ajm]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ajg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ajg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ajg RCSB], [http://www.ebi.ac.uk/pdbsum/4ajg PDBsum]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/PDE10_HUMAN PDE10_HUMAN]] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.<ref>PMID:17389385</ref>
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{{STRUCTURE_4ajg| PDB=4ajg | SCENE= }}
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==See Also==
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*[[Phosphodiesterase|Phosphodiesterase]]
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===Identification and structural characterization of PDE10 fragment inhibitors===
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== References ==
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<references/>
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__TOC__
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==About this Structure==
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</StructureSection>
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[[4ajg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AJG OCA].
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Aharony, D.]]
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[[Category: Aharony, D]]
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[[Category: Akerud, T.]]
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[[Category: Akerud, T]]
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[[Category: Albert, J S.]]
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[[Category: Albert, J S]]
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[[Category: Back, E.]]
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[[Category: Back, E]]
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[[Category: Geschwindner, S.]]
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[[Category: Geschwindner, S]]
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[[Category: Hillertz, P.]]
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[[Category: Hillertz, P]]
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[[Category: Horsefeld, R.]]
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[[Category: Horsefeld, R]]
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[[Category: Johansson, P.]]
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[[Category: Johansson, P]]
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[[Category: Scott, C.]]
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[[Category: Scott, C]]
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[[Category: Spadola, L.]]
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[[Category: Spadola, L]]
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[[Category: Spear, N.]]
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[[Category: Spear, N]]
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[[Category: Tian, G.]]
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[[Category: Tian, G]]
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[[Category: Tigerstrom, A.]]
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[[Category: Tigerstrom, A]]
[[Category: Hydrolase]]
[[Category: Hydrolase]]

Revision as of 20:27, 25 December 2014

Identification and structural characterization of PDE10 fragment inhibitors

4ajg, resolution 2.30Å

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