4ajm

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[[Image:4ajm.jpg|left|200px]]
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==Development of a plate-based optical biosensor methodology to identify PDE10 fragment inhibitors==
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<StructureSection load='4ajm' size='340' side='right' caption='[[4ajm]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4ajm]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AJM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AJM FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3A6:3-AMINO-6-FLUORO-2-[4-(2-METHYLPYRIDIN-4-YL)PHENYL]-N-(METHYLSULFONYL)QUINOLINE-4-CARBOXAMIDE'>3A6</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1lrb|1lrb]], [[2wey|2wey]], [[2y0j|2y0j]], [[4ael|4ael]], [[4ajd|4ajd]], [[4ajf|4ajf]], [[4ajg|4ajg]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ajm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ajm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ajm RCSB], [http://www.ebi.ac.uk/pdbsum/4ajm PDBsum]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/PDE10_HUMAN PDE10_HUMAN]] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.<ref>PMID:17389385</ref>
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{{STRUCTURE_4ajm| PDB=4ajm | SCENE= }}
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==See Also==
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*[[Phosphodiesterase|Phosphodiesterase]]
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===Development of a plate-based optical biosensor methodology to identify PDE10 fragment inhibitors===
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== References ==
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<references/>
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__TOC__
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==About this Structure==
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</StructureSection>
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[[4ajm]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AJM OCA].
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Aharony, D.]]
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[[Category: Aharony, D]]
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[[Category: Akerud, T.]]
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[[Category: Akerud, T]]
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[[Category: Albert, J S.]]
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[[Category: Albert, J S]]
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[[Category: Back, E.]]
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[[Category: Back, E]]
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[[Category: Geschwindner, S.]]
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[[Category: Geschwindner, S]]
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[[Category: Hillertz, P.]]
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[[Category: Hillertz, P]]
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[[Category: Horsefeld, R.]]
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[[Category: Horsefeld, R]]
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[[Category: Johansson, P.]]
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[[Category: Johansson, P]]
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[[Category: Scott, C.]]
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[[Category: Scott, C]]
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[[Category: Spadola, L.]]
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[[Category: Spadola, L]]
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[[Category: Spear, N.]]
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[[Category: Spear, N]]
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[[Category: Tian, G.]]
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[[Category: Tian, G]]
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[[Category: Tigerstrom, A.]]
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[[Category: Tigerstrom, A]]
[[Category: Hydrolase]]
[[Category: Hydrolase]]

Revision as of 07:11, 24 December 2014

Development of a plate-based optical biosensor methodology to identify PDE10 fragment inhibitors

4ajm, resolution 2.40Å

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