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4enf
From Proteopedia
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{{STRUCTURE_4enf| PDB=4enf | SCENE= }} | {{STRUCTURE_4enf| PDB=4enf | SCENE= }} | ||
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===Crystal structure of the cap-binding domain of polymerase basic protein 2 from influenza virus A/Puerto Rico/8/34(h1n1)=== | ===Crystal structure of the cap-binding domain of polymerase basic protein 2 from influenza virus A/Puerto Rico/8/34(h1n1)=== | ||
| + | {{ABSTRACT_PUBMED_23436652}} | ||
| + | ==Function== | ||
| + | [[http://www.uniprot.org/uniprot/PB2_I34A1 PB2_I34A1]] Involved in transcription initiation and cap-stealing mechanism, in which cellular capped pre-mRNA are used to generate primers for viral transcription. Binds the cap of the target pre-RNA which is subsequently cleaved by PB1. May play a role in genome replication (By similarity). | ||
==About this Structure== | ==About this Structure== | ||
[[4enf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus_(a/puerto_rico/8/1934(h1n1)) Influenza a virus (a/puerto rico/8/1934(h1n1))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ENF OCA]. | [[4enf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus_(a/puerto_rico/8/1934(h1n1)) Influenza a virus (a/puerto rico/8/1934(h1n1))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ENF OCA]. | ||
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| + | ==Reference== | ||
| + | <ref group="xtra">PMID:023436652</ref><references group="xtra"/><references/> | ||
[[Category: Liu, Y.]] | [[Category: Liu, Y.]] | ||
[[Category: Meng, G.]] | [[Category: Meng, G.]] | ||
Revision as of 04:13, 18 July 2013
Contents |
Crystal structure of the cap-binding domain of polymerase basic protein 2 from influenza virus A/Puerto Rico/8/34(h1n1)
Template:ABSTRACT PUBMED 23436652
Function
[PB2_I34A1] Involved in transcription initiation and cap-stealing mechanism, in which cellular capped pre-mRNA are used to generate primers for viral transcription. Binds the cap of the target pre-RNA which is subsequently cleaved by PB1. May play a role in genome replication (By similarity).
About this Structure
4enf is a 1 chain structure with sequence from Influenza a virus (a/puerto rico/8/1934(h1n1)). Full crystallographic information is available from OCA.
Reference
- Liu Y, Qin K, Meng G, Zhang J, Zhou J, Zhao G, Luo M, Zheng X. Structural and functional characterization of K339T substitution identified in the PB2 subunit cap-binding pocket of influenza A virus. J Biol Chem. 2013 Apr 19;288(16):11013-23. doi: 10.1074/jbc.M112.392878. Epub, 2013 Feb 22. PMID:23436652 doi:10.1074/jbc.M112.392878
