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Cyclophilin

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=== Cyclophilin-A ===
=== Cyclophilin-A ===
- 
[[2x25]], [[2x2a]], [[3k0m]], [[3k0n]], [[1w8l]], [[1w8m]], [[1w8v]], [[1rmh]], [[2cpl]] – hCyp-A – human<br />
[[2x25]], [[2x2a]], [[3k0m]], [[3k0n]], [[1w8l]], [[1w8m]], [[1w8v]], [[1rmh]], [[2cpl]] – hCyp-A – human<br />
[[1oca]] – hCyp-A - NMR<br />
[[1oca]] – hCyp-A - NMR<br />
[[3k0o]], [[3k0p]], [[3k0q]], [[3k0r]], [[2alf]] – hCyp-A (mutant)<br />
[[3k0o]], [[3k0p]], [[3k0q]], [[3k0r]], [[2alf]] – hCyp-A (mutant)<br />
-
[[2a2c]], [[1cwa]], [[1cwb]], [[1cwc]] – hCyp-A+cyclosporin A<br />
+
[[2a2c]], [[1cwa]], [[1cwb]], [[1cwc]], [[2x2c]] – hCyp-A+cyclosporin A<br />
[[3cys]] - hCyp-A+cyclosporin A - NMR<br />
[[3cys]] - hCyp-A+cyclosporin A - NMR<br />
[[1cwj]], [[1bck]], [[1cwi]], [[1cwo]], [[1cwf]], [[1cwh]], [[1cwk]], [[1cwl]], [[1cwm]], [[1mik]] - hCyp-A+cyclosporin A derivative<br />
[[1cwj]], [[1bck]], [[1cwi]], [[1cwo]], [[1cwf]], [[1cwh]], [[1cwk]], [[1cwl]], [[1cwm]], [[1mik]] - hCyp-A+cyclosporin A derivative<br />
Line 41: Line 40:
[[3odi]], [[3odl]] – hCyp-A+voclosporin<br />
[[3odi]], [[3odl]] – hCyp-A+voclosporin<br />
[[2x2d]], [[1m9c]], [[1m9d]], [[1m9e]], [[1m9f]], [[1m9x]], [[1m9y]], [[1awq]], [[1awr]], [[1aws]], [[1awt]], [[1awu]], [[1awv]], [[1ak4]], [[1fgl]] - hCyp-A+HIV-1 N-terminal capsid domain<br />
[[2x2d]], [[1m9c]], [[1m9d]], [[1m9e]], [[1m9f]], [[1m9x]], [[1m9y]], [[1awq]], [[1awr]], [[1aws]], [[1awt]], [[1awu]], [[1awv]], [[1ak4]], [[1fgl]] - hCyp-A+HIV-1 N-terminal capsid domain<br />
 +
[[4dga]], [[4dgb]], [[4dgc]] - RmCyp-A+HIV-1 Cyp-binding domain capsid protein (mutant) – ''Rhesus macaque''<br />
 +
[[4dge]] - RmCyp-A (mutant) +HIV-1 Cyp-binding domain capsid protein (mutant) <br />
 +
[[4dgd]] - RmCyp-A (mutant)<br />
[[1zkf]] – hCyp-A+suc-AGPF-pNA<br />
[[1zkf]] – hCyp-A+suc-AGPF-pNA<br />
[[1ynd]], [[1nmk]] – hCyp-A+ sanglifehrin<br />
[[1ynd]], [[1nmk]] – hCyp-A+ sanglifehrin<br />
Line 52: Line 54:
[[2xgy]] – Cyp-A+RELIK capsid N-terminal - rabbit<br />
[[2xgy]] – Cyp-A+RELIK capsid N-terminal - rabbit<br />
[[3o7t]] – NpCyp-A – ''Noniliophthora perniciosa''<br />
[[3o7t]] – NpCyp-A – ''Noniliophthora perniciosa''<br />
-
[[3pmp]] - NpCyp-A + cyclosporin A
+
[[3pmp]] - NpCyp-A + cyclosporin A<br />
 +
[[3rdd]] – hCyp-A + inhibitor<br />
=== Cyclophilin-B ===
=== Cyclophilin-B ===
- 
[[3ich]] – hCyp-B<br />
[[3ich]] – hCyp-B<br />
Line 63: Line 65:
[[1cyn]] – hCyp-B +cyclosporin A derivative<br />
[[1cyn]] – hCyp-B +cyclosporin A derivative<br />
[[1j2a]] – EcCyp-B (mutant)<br />
[[1j2a]] – EcCyp-B (mutant)<br />
- 
=== Cyclophilin-C ===
=== Cyclophilin-C ===
- 
[[2esl]] - hCyp-C+cyclosporin A<br />
[[2esl]] - hCyp-C+cyclosporin A<br />
[[2rmc]] - Cyp-C+cyclosporin A – mouse<br />
[[2rmc]] - Cyp-C+cyclosporin A – mouse<br />
- 
=== Cyclophilin-D ===
=== Cyclophilin-D ===
- 
[[2bit]], [[3qyu]] – hCyp-D<br />
[[2bit]], [[3qyu]] – hCyp-D<br />
[[2viu]] – hCyp-D+DMSO<br />
[[2viu]] – hCyp-D+DMSO<br />
[[2z6w]] - hCyp-D+cyclosporin A<br />
[[2z6w]] - hCyp-D+cyclosporin A<br />
- 
=== Cyclophilin-E ===
=== Cyclophilin-E ===
- 
[[2kyx]], [[1zmf]] – hCyp-E PPIASE domain<br />
[[2kyx]], [[1zmf]] – hCyp-E PPIASE domain<br />
Line 89: Line 85:
[[2kyx]] – hCyp-E RRM domain – NMR<br />
[[2kyx]] – hCyp-E RRM domain – NMR<br />
[[3lpy]], [[3mdf]] - hCyp-E RRM domain<br />
[[3lpy]], [[3mdf]] - hCyp-E RRM domain<br />
- 
=== Cyclophilin-G ===
=== Cyclophilin-G ===
- 
[[2wfi]], [[2gw2]] - hCyp-G PPIASE domain<br />
[[2wfi]], [[2gw2]] - hCyp-G PPIASE domain<br />
[[2wfj]] - hCyp-G PPIASE domain+cyclosporin A<br />
[[2wfj]] - hCyp-G PPIASE domain+cyclosporin A<br />
- 
=== Cyclophilin-H ===
=== Cyclophilin-H ===
- 
[[1mzw]] – hCyp-H+peptide<br />
[[1mzw]] – hCyp-H+peptide<br />
- 
=== Cyclophilin-J ===
=== Cyclophilin-J ===
- 
[[2ok3]], [[1xyh]] - hCyp-J<br />
[[2ok3]], [[1xyh]] - hCyp-J<br />
[[2oju]] - hCyp-J+cyclosporin A<br />
[[2oju]] - hCyp-J+cyclosporin A<br />
- 
=== Cyclophilin-3 ===
=== Cyclophilin-3 ===
- 
[[2igv]], [[2igw]], [[1e8k]] – CeCyp-3+dipeptide – ''Caenorhabditis elegans''<br />
[[2igv]], [[2igw]], [[1e8k]] – CeCyp-3+dipeptide – ''Caenorhabditis elegans''<br />
[[1dyw]] - CeCyp-3<br />
[[1dyw]] - CeCyp-3<br />
[[1e3b]] – CeCyp-3+AUP(ET)3<br />
[[1e3b]] – CeCyp-3+AUP(ET)3<br />
- 
=== Cyclophilin-5 ===
=== Cyclophilin-5 ===
- 
[[1h0p]] – CeCyp-5 (mutant) <br />
[[1h0p]] – CeCyp-5 (mutant) <br />
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[[1ihg]], [[1iip]] – Cyp-40 – bovine<br />
[[1ihg]], [[1iip]] – Cyp-40 – bovine<br />
- 
=== Cyclophilin ===
=== Cyclophilin ===
- 
[[3bo7]] - TgCyp+cyclosporin A - ''Toxoplasma gondii''<br />
[[3bo7]] - TgCyp+cyclosporin A - ''Toxoplasma gondii''<br />
Line 152: Line 136:
[[2ko7]] – BpCyp+inhibitor – ''Burkholderia pseudomallei''<br />
[[2ko7]] – BpCyp+inhibitor – ''Burkholderia pseudomallei''<br />
[[2ke0]] – BpCyp – NMR
[[2ke0]] – BpCyp – NMR
- 
- 
-
=== Rotamase (FKBP) ===
 
- 
- 
-
[[1fks]], [[1fkt]], [[1fkr]], [[2kfw]] – EcFKBP – NMR<br />
 
-
[[1q6h]], [[1q6u]] – EcFKBP<br />
 
-
[[1q6i]] – EcFKBP+FK-506<br />
 
-
[[3jxv]], [[3jym]] – FKBP73 – wheat<br />
 
-
[[3mdy]] – hFKBP-1A+BMPR1B<br />
 
-
[[3h9r]] - hFKBP-1A+ activin receptor type I<br />
 
-
[[1j4r]] – hFKBP-1+FKB-001<br />
 
-
[[2ppp]], [[2ppn]], [[2dg3]], [[1d6o]] – hFKBP-12<br />
 
-
[[2ppo]] – hFKBP-12 (mutant)<br />
 
-
[[2dg4]], [[1fkb]] - hFKBP-12+rapamycin<br />
 
-
[[2fap]], [[1nsg]], [[1fap]] - hFKBP-12+rapamycin+FRB<br />
 
-
[[1f40]] - hFKBP-12+GPI-1046<br />
 
-
[[1a7x]] – hFKBP-12+FK-1012<br />
 
-
[[1d7h]], [[1d7i]], [[1d7j]], [[1fkg]], [[1fkh]], [[1fki]] - hFKBP-12+ligand<br />
 
-
[[2dg9]] - hFKBP-12 (mutant)+rapamycin<br />
 
-
[[1fkl]] - cFKBP-12+rapamycin - cow<br />
 
-
[[2pbc]] - hFKBP-13<br />
 
-
[[1y0o]], [[1u79]] – AtFKBP-13 - ''Arabidopsis thaliana''<br />
 
-
[[2kfv]] – hFKBP-25 N-terminal<br />
 
-
[[2vn1]] – PfFKBP-35 FK506-binding domain+FK506<br />
 
-
[[3b7x]] – hFKBP-36 <br />
 
-
[[2if4]] – AtFKBP<br />
 
-
[[2f4e]] - AtFKBP-42 N-terminal<br />
 
-
[[1kt0]], [[1kt1]] – hFKBP-51 (mutant)<br />
 
-
[[1ix5]] – FKBP – ''Methanothermococcus thermolithotrophicus'' – NMR<br />
 
-
[[1bl4]] – hFKBP (mutant)+inhibitor<br />
 
-
[[1bkf]] – hFKBP (mutant)+FK-506<br />
 
-
[[1fkf]] - hFKBP+FK-506<br />
 
-
[[1fkr]], [[1fks]], [[1fkt]] – hFKBP - NMR<br />
 
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 10:48, 23 June 2013

Image:2x25.jpg
Crystal Structure of human Cyclophilin-A, 2x25

Template:STRUCTURE 2x25










Cyclophilin (Cyp) binds cyclosporin. They are peptidylprolyl isomerases which catalyze the isomerisation of proline. The Cyp-A/cyclosporin A complex inhibits organ rejection. Cyp-D is a component of the mitochondria permeability pore. Rotamase such as FKBP is a prokaryotic Cyp which is not inhibited by cyclosporin but by FK-506 – an immunosuppressive drug. The images at the left and at the right correspond to one representative Cyclophilin, i.e. crystal structure of human Cyclophilin A (2x25).

Contents

3D Structures of Cyclophilin

Updated on 23-June-2013

Cyclophilin-A

2x25, 2x2a, 3k0m, 3k0n, 1w8l, 1w8m, 1w8v, 1rmh, 2cpl – hCyp-A – human
1oca – hCyp-A - NMR
3k0o, 3k0p, 3k0q, 3k0r, 2alf – hCyp-A (mutant)
2a2c, 1cwa, 1cwb, 1cwc, 2x2c – hCyp-A+cyclosporin A
3cys - hCyp-A+cyclosporin A - NMR
1cwj, 1bck, 1cwi, 1cwo, 1cwf, 1cwh, 1cwk, 1cwl, 1cwm, 1mik - hCyp-A+cyclosporin A derivative
2rma, 2rmb - hCyp-A+cyclosporin A+cyclosporin A derivative
1mf8, 1m63 - hCyp-A+cyclosporin A+ calcineurin subunits A,B
3odi, 3odl – hCyp-A+voclosporin
2x2d, 1m9c, 1m9d, 1m9e, 1m9f, 1m9x, 1m9y, 1awq, 1awr, 1aws, 1awt, 1awu, 1awv, 1ak4, 1fgl - hCyp-A+HIV-1 N-terminal capsid domain
4dga, 4dgb, 4dgc - RmCyp-A+HIV-1 Cyp-binding domain capsid protein (mutant) – Rhesus macaque
4dge - RmCyp-A (mutant) +HIV-1 Cyp-binding domain capsid protein (mutant)
4dgd - RmCyp-A (mutant)
1zkf – hCyp-A+suc-AGPF-pNA
1ynd, 1nmk – hCyp-A+ sanglifehrin
2cyh, 3cyh, 4cyh, 5cyh - hCyp-A+dipeptide
1vbs, 1vbt – hCyp-A+tetrapeptide
1vdn – yCyp-A+peptidyl coumarin – yeast
1ist – yCyp-A
1w74 – Cyp-A – Mycobacterium tuberculosis
1lop - EcCyp-A+peptidyl nitroanilide - Escherichia coli
1csa – EcCyp-A+ cyclosporin A – NMR
2xgy – Cyp-A+RELIK capsid N-terminal - rabbit
3o7t – NpCyp-A – Noniliophthora perniciosa
3pmp - NpCyp-A + cyclosporin A
3rdd – hCyp-A + inhibitor

Cyclophilin-B

3ich – hCyp-B
3ici - hCyp-B+calmegin fragment
1v9t – EcCyp-B+peptidyl nitroanilide
1vai - EcCyp-B+peptidyl coumarin
1cyn – hCyp-B +cyclosporin A derivative
1j2a – EcCyp-B (mutant)

Cyclophilin-C

2esl - hCyp-C+cyclosporin A
2rmc - Cyp-C+cyclosporin A – mouse

Cyclophilin-D

2bit, 3qyu – hCyp-D
2viu – hCyp-D+DMSO
2z6w - hCyp-D+cyclosporin A

Cyclophilin-E

2kyx, 1zmf – hCyp-E PPIASE domain
2r99 - hCyp-E ABH-like domain
2cqb – hCyp-E RNA recognition motif
2ck1, 2cmt – Cyp-E – Schistosoma mansoni
2kyx – hCyp-E RRM domain – NMR
3lpy, 3mdf - hCyp-E RRM domain

Cyclophilin-G

2wfi, 2gw2 - hCyp-G PPIASE domain
2wfj - hCyp-G PPIASE domain+cyclosporin A

Cyclophilin-H

1mzw – hCyp-H+peptide

Cyclophilin-J

2ok3, 1xyh - hCyp-J
2oju - hCyp-J+cyclosporin A

Cyclophilin-3

2igv, 2igw, 1e8k – CeCyp-3+dipeptide – Caenorhabditis elegans
1dyw - CeCyp-3
1e3b – CeCyp-3+AUP(ET)3

Cyclophilin-5

1h0p – CeCyp-5 (mutant)

Cyclophilin-40

1ihg, 1iip – Cyp-40 – bovine

Cyclophilin

3bo7 - TgCyp+cyclosporin A - Toxoplasma gondii
2nul – EcCyp
1clh – EcCyp – NMR
1qoi – hCyp SNUCYP-20
3k2c – Cyp – Encephalitozoon cuniculi
3eov - LdCyp+cyclosporin A – Leishmania donovani
3bt8 – LdCyp
2haq – LdCyp-A
2hqj – Cyp – Leishmania major
3bkp – TgCyp
2cfe – Cyp – Malassezia sympodialis
2c3b – Cyp – Aspergillus fumigatus
1z81 – Cyp – Plasmodium Yoelli
1qng – PfCyp+cyclosporin A – Plasmodium falciparum
1qnh – PfCyp (mutant)+cyclosporin A
1xo7 – TcCyp – Trypanosoma cruzi
1xq7 - TcCyp+cyclosporin A
1a58 - Cyp – Brugia malayi
2ko7 – BpCyp+inhibitor – Burkholderia pseudomallei
2ke0 – BpCyp – NMR

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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