This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
Glycerol kinase
From Proteopedia
| Line 11: | Line 11: | ||
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
| + | |||
| + | ===Glycerol kinase=== | ||
[[1r59]] – EncGK – ''Enterococcus casseliflavus''<br /> | [[1r59]] – EncGK – ''Enterococcus casseliflavus''<br /> | ||
| Line 18: | Line 20: | ||
[[3gg4]] – GK – ''Yersinia pseudotuberculosis'' | [[3gg4]] – GK – ''Yersinia pseudotuberculosis'' | ||
| - | + | ===Glycerol kinase binary complex with glycerol=== | |
[[1xup]] - EncGK + glycerol<br /> | [[1xup]] - EncGK + glycerol<br /> | ||
| Line 26: | Line 28: | ||
[[1bu6]], [[3ezw]] - EcGK (mutant) + glycerol<br /> | [[1bu6]], [[3ezw]] - EcGK (mutant) + glycerol<br /> | ||
| - | + | ===Glycerol kinase ternary complex=== | |
[[1gla]] – EcGK + IIA(Glc) + glycerol – ''Escherichia coli''<br /> | [[1gla]] – EcGK + IIA(Glc) + glycerol – ''Escherichia coli''<br /> | ||
Revision as of 09:10, 27 August 2014
Template:STRUCTURE 1r59
Glycerol kinase (GK) phosphorylates glycerol forming glycerol 3-phosphate (G3P) using Mg-ATP as phosphate source. GK is a key enzyme in glycerol uptake and metabolism. Mutations of GK gene cause GK deficiency syndrome. PK is a multi-subunit allosteric enzyme. Its activity can be inhibited by fructose 1,6-bisphosphate (FBP) and by the glucose-specific phosphocarrier IIA(Glc). PK cofactor is a Zn atom which binds to the dimer.
Contents |
3D structures of glycerol kinase
Updated on 27-August-2014
Glycerol kinase
1r59 – EncGK – Enterococcus casseliflavus
2dpn - GK - Thermus thermophilus
2d4w - GK - Cellulomonas
2zf5 - GK - Thermococcus kodakarensis
3gg4 – GK – Yersinia pseudotuberculosis
Glycerol kinase binary complex with glycerol
1xup - EncGK + glycerol
3flc, 3d7e, 3h3n, 3h46 - EncGK (mutant) + glycerol
3g25 - SaGK + glycerol– Staphylococcus aureus
4e1j – GK + glycerol – Sinorhizobium meliloti
1bu6, 3ezw - EcGK (mutant) + glycerol
Glycerol kinase ternary complex
1gla – EcGK + IIA(Glc) + glycerol – Escherichia coli
1glb - EcGK + IIA(Glc) + ADP + glycerol
1glc, 1gld, 1gle – EcGK + G3P + ADP
1glf - EcGK + phosphate + ADP + glycerol
1bo5 - EcGK + FBP + glycerol
1bot - EcGK + piperazine derivative + glycerol
1bwf, 1glj, 1gll - EcGK (mutant) + ATP analog + glycerol
3ge1 - SaGK + ADP + glycerol
3h3o - EncGK (mutant) + phosphate + glycerol
3h45 - EncGK (mutant) + phosphate + ethylene glycol
