We apologize for Proteopedia being slow to respond. For the past two years, a new implementation of Proteopedia has been being built. Soon, it will replace this 18-year old system. All existing content will be moved to the new system at a date that will be announced here.

Hirudin

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 23: Line 23:
-
[[Hirudin]] (Hir) is a powerful anticoagulant which is found in the leech salivary glands. It is an inhibitor of thrombin (Thr) which converts [[Fibrinogen|fibrinogen]] to [[Fibrin|fibrin]] upon blood clotting. Thrombin is produced upon enzymatic cleavage of prothrombin (ProThr). Hirugen (Hirg) is a dodecapeptide of the C-terminal of Hir (sequence NDGDFEEIPEEYL). The images at the left and at the right correspond to one representative Hirudin, ''i.e.'' the NMR Structure of Hirudin ([[1hic]]).
+
[[Hirudin]] (Hir) is a powerful anticoagulant which is found in the leech salivary glands. It is an inhibitor of thrombin (Thr) which converts [[Fibrinogen|fibrinogen]] to [[Fibrin|fibrin]] upon blood clotting. Thrombin is produced upon enzymatic cleavage of prothrombin (ProThr). Hirugen (Hirg) is a dodecapeptide of the C-terminal of Hir (sequence NDGDFEEIPEEYL). The images at the left and at the right correspond to one representative Hirudin, ''i.e.'' the NMR Structure of Hirudin ([[1hic]]). For additional details see[[User:Sean Swale/Human Thrombin Inhibitor]].
{{TOC limit|limit=2}}
{{TOC limit|limit=2}}
Line 39: Line 39:
[[1hrt]], [[3htc]], [[4htc]] - Hir +hThr L&H chains<br />
[[1hrt]], [[3htc]], [[4htc]] - Hir +hThr L&H chains<br />
-
[[3da9]] - Hir peptide+hThr L&H chains<br />
+
[[3da9]], [[3utu]] - Hir peptide+hThr L&H chains<br />
[[3qtv]], [[3qwc]], [[3qx5]] - Hir peptide + hThr L&H chains + pyridine derivative<br />
[[3qtv]], [[3qwc]], [[3qx5]] - Hir peptide + hThr L&H chains + pyridine derivative<br />
[[3rlw]], [[3rly]], [[3rm0]], [[3rm2]], [[3rml]], [[3rmm]], [[3rmn]], [[3rmo]] - Hir peptide + hThr L&H chains + inhibitor<br />
[[3rlw]], [[3rly]], [[3rm0]], [[3rm2]], [[3rml]], [[3rmm]], [[3rmn]], [[3rmo]] - Hir peptide + hThr L&H chains + inhibitor<br />

Revision as of 12:20, 18 March 2013

Image:1hic.png
NMR Structure of Hirudin, 1hic

Template:STRUCTURE 1hic












Hirudin (Hir) is a powerful anticoagulant which is found in the leech salivary glands. It is an inhibitor of thrombin (Thr) which converts fibrinogen to fibrin upon blood clotting. Thrombin is produced upon enzymatic cleavage of prothrombin (ProThr). Hirugen (Hirg) is a dodecapeptide of the C-terminal of Hir (sequence NDGDFEEIPEEYL). The images at the left and at the right correspond to one representative Hirudin, i.e. the NMR Structure of Hirudin (1hic). For additional details seeUser:Sean Swale/Human Thrombin Inhibitor.

Contents

3D Structures of Hirudin

Updated on 18-March-2013

Hirudin

1hic, 2hir, 4hir, 5hir, 6hir – Hir – NMR
2joo - Hir – NMR

Hirudin + Thrombin light and heavy chains

1hrt, 3htc, 4htc - Hir +hThr L&H chains
3da9, 3utu - Hir peptide+hThr L&H chains
3qtv, 3qwc, 3qx5 - Hir peptide + hThr L&H chains + pyridine derivative
3rlw, 3rly, 3rm0, 3rm2, 3rml, 3rmm, 3rmn, 3rmo - Hir peptide + hThr L&H chains + inhibitor
3qto - Hir +hThr L&H chains + pyridine derivative

Hirugen + Thrombin light and heavy chains

2zhe, 2zhf, 2zhw, 2zg0, 2zfq, 2zfr, 1c5l, 1hxf, 1hah, 1hai, 1abi, 1abj, 1hgt, 2uuf - Hirg+ hThr L&H chains

Hirugen + Prothrombin

2cn0, 3c1k – Hirg+ hProThr
1t4u, 1t4v, 1o5g, 1g30, 1g32, 1twx, 3tu7 - Hirg+hProThr+inhibitor

Hirugen + Prethrombin

1hag – Hirg+hPreThr

Hirugen + Thrombin heavy chain

1nm6 – Hirg+ hThr H chain
1nt1 - Hirg+ hThr H chain+inhibitor

Hirugen + Thrombin light and heavy chains+inhibitor

1fph, 7kme - Hirg +hThr L&H chains+polypeptide
1hxe - Hirg +hThr L&H chains+Rb
1ypk, 1riw, 1mu6, 1mu8, 1mue, 1no9, 1oyt, 1o2g, 1ny2, 1gj4, 1gj5, 1kts, 1ktt, 1ghv, 1ghw, 1ghx, 1ghy, 1h8i, 1h8d, 1c5n, 1c5o, 1c1u, 1c1v, 1c1w, 1qj1, 1qj6, 1qj7, 1qbv, 1bcu, 1a2c, 1a61, 1a46, 1a5g, 1b5g, 1ad8, 1ai8, 1tom, 1bmm, 1bmn, 1lhc, 1lhd, 1lhe, 1lhf, 1lhg, 1uma, 1aht, 1fpc, 3hat, 1tmu, 1dwb, 1dwc, 1dwd, 1dwe, 1tmb, 3f68, 3eq0, 3dt0, 3dux, 3dhk, 2znk, 2zo3, 3d49, 2zhq, 2zi2, 2ziq, 2zff, 2zfp, 2zgb, 2zgx, 2zf0, 2zc9, 2zda, 2zdv, 3egk, 2pw8, 3c27, 2r2m, 2cf8, 2cf9, 2bdy, 2v3h, 2v3o, 1w7g, 1ype, 1ypg, 1ypj, 3biu, 3biv, 1doj, 1ypl, 1ypm, 1vzq, 1way, 1wbg, 1k21, 1k22, 1afe, 1ae8 ,1a3b, 1a3e, 1vr1, 2bvr, 2bvs, 2bvx, 2bxt, 2bxu, 2gde, 2pks, 3ldx, 3p17 – Hirg+ hThr L&H chains+inhibitor


Hirugen+Thrombin light and heavy chains+ε-thrombin

1vit - Hirg+hThr L&H chains+epsilon-hThr


Hirugen+ α-Thrombin +inhibitor

1zrb, 1z71, 1sl3, 1ta2, 1ta6, 1zgi, 1zgv, 2uuk, 2uuj, 2jh0, 2jh5, 2jh6, 2c8w, 2c8x, 2c8y, 2c8z, 2c90, 2c93, 8kme – Hirg+α-hThr+inhibitor

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

Retrieved from "http://52.214.119.220/wiki/index.php/Hirudin"
Personal tools