2m0r
From Proteopedia
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| - | + | ==Solution structure and dynamics of human S100A14== | |
| - | + | <StructureSection load='2m0r' size='340' side='right' caption='[[2m0r]], [[NMR_Ensembles_of_Models | 30 NMR models]]' scene=''> | |
| - | === | + | == Structural highlights == |
| - | + | <table><tr><td colspan='2'>[[2m0r]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M0R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2M0R FirstGlance]. <br> | |
| + | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">S100A14, S100A15 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2m0r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m0r OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2m0r RCSB], [http://www.ebi.ac.uk/pdbsum/2m0r PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Human S100A14 is a member of the EF-hand calcium-binding protein family that has only recently been described in terms of its functional and pathological properties. The protein is overexpressed in a variety of tumor cells and it has been shown to trigger receptor for advanced glycation end products (RAGE)-dependent signaling in cell cultures. The solution structure of homodimeric S100A14 in the apo state has been solved at physiological temperature. It is shown that the protein does not bind calcium(II) ions and exhibits a "semi-open" conformation that thus represents the physiological structure of the S100A14. The lack of two ligands in the canonical EF-hand calcium(II)-binding site explains the negligible affinity for calcium(II) in solution, and the exposed cysteines and histidine account for the observed precipitation in the presence of zinc(II) or copper(II) ions. | ||
| - | + | Solution structure and dynamics of human S100A14.,Bertini I, Borsi V, Cerofolini L, Das Gupta S, Fragai M, Luchinat C J Biol Inorg Chem. 2012 Nov 30. PMID:23197251<ref>PMID:23197251</ref> | |
| - | + | ||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[S100 protein|S100 protein]] | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Bertini, I | + | [[Category: Bertini, I]] |
| - | [[Category: Borsi, V | + | [[Category: Borsi, V]] |
| - | [[Category: Cerofolini, L | + | [[Category: Cerofolini, L]] |
| - | [[Category: Fragai, M | + | [[Category: Fragai, M]] |
| - | [[Category: Gupta, S Das | + | [[Category: Gupta, S Das]] |
| - | [[Category: Luchinat, C | + | [[Category: Luchinat, C]] |
[[Category: Ef-hand protein]] | [[Category: Ef-hand protein]] | ||
[[Category: Metal binding protein]] | [[Category: Metal binding protein]] | ||
[[Category: Protein dynamic]] | [[Category: Protein dynamic]] | ||
Revision as of 14:17, 17 December 2014
Solution structure and dynamics of human S100A14
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