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4acq
From Proteopedia
(Difference between revisions)
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| - | + | ==Alpha-2 Macroglobulin== | |
| - | + | <StructureSection load='4acq' size='340' side='right' caption='[[4acq]], [[Resolution|resolution]] 4.30Å' scene=''> | |
| - | === | + | == Structural highlights == |
| - | + | <table><tr><td colspan='2'>[[4acq]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ACQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ACQ FirstGlance]. <br> | |
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene></td></tr> | ||
| + | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MEQ:N5-METHYLGLUTAMINE'>MEQ</scene></td></tr> | ||
| + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1bv8|1bv8]]</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4acq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4acq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4acq RCSB], [http://www.ebi.ac.uk/pdbsum/4acq PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | I'm your Venus: The crystal structure of the human methylamine-induced form of alpha(2) -macroglobulin (alpha(2) M) shows its large central cavity can accommodate two medium-sized proteinases (see structure, front part clipped off to better show central cavity). Twelve major entrances provide access for small substrates to the cavity and the still-active trapped "prey". The structure unveils the molecular basis of the unique "venus flytrap" mechanism of alpha(2) M. | ||
| - | + | The Crystal Structure of Human alpha(2) -Macroglobulin Reveals a Unique Molecular Cage.,Marrero A, Duquerroy S, Trapani S, Goulas T, Guevara T, Andersen GR, Navaza J, Sottrup-Jensen L, Gomis-Ruth FX Angew Chem Int Ed Engl. 2012 Jan 31. doi: 10.1002/anie.201108015. PMID:22290936<ref>PMID:22290936</ref> | |
| - | + | ||
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | < | + | </div> |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Andersen, G R | + | [[Category: Andersen, G R]] |
| - | [[Category: Duquerroy, S | + | [[Category: Duquerroy, S]] |
| - | [[Category: Gomis-Ruth, F X | + | [[Category: Gomis-Ruth, F X]] |
| - | [[Category: Goulas, T | + | [[Category: Goulas, T]] |
| - | [[Category: Guevara, T | + | [[Category: Guevara, T]] |
| - | [[Category: Marrero, A | + | [[Category: Marrero, A]] |
| - | [[Category: Navaza, J | + | [[Category: Navaza, J]] |
| - | [[Category: Sottrup-Jensen, L | + | [[Category: Sottrup-Jensen, L]] |
| - | [[Category: Trapani, S | + | [[Category: Trapani, S]] |
[[Category: Blood plasma inhibitor]] | [[Category: Blood plasma inhibitor]] | ||
[[Category: Conformational change]] | [[Category: Conformational change]] | ||
Revision as of 09:06, 17 December 2014
Alpha-2 Macroglobulin
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