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3sm5

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{{STRUCTURE_3sm5| PDB=3sm5 | SCENE= }}
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==Influenza hemagglutinin in complex with a neutralizing antibody==
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===Influenza hemagglutinin in complex with a neutralizing antibody===
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<StructureSection load='3sm5' size='340' side='right' caption='[[3sm5]], [[Resolution|resolution]] 3.19&Aring;' scene=''>
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{{ABSTRACT_PUBMED_21825125}}
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3sm5]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Influenza_a_virus Influenza a virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SM5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3SM5 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HA, Hemagglutinin (HA) ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11320 Influenza A virus])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3sm5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sm5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3sm5 RCSB], [http://www.ebi.ac.uk/pdbsum/3sm5 PDBsum]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Seasonal antigenic drift of circulating influenza virus leads to a requirement for frequent changes in vaccine composition, because exposure or vaccination elicits human antibodies with limited cross-neutralization of drifted strains. We describe a human monoclonal antibody, CH65, obtained by isolating rearranged heavy- and light-chain genes from sorted single plasma cells, coming from a subject immunized with the 2007 trivalent influenza vaccine. The crystal structure of a complex of the hemagglutinin (HA) from H1N1 strain A/Solomon Islands/3/2006 with the Fab of CH65 shows that the tip of the CH65 heavy-chain complementarity determining region 3 (CDR3) inserts into the receptor binding pocket on HA1, mimicking in many respects the interaction of the physiological receptor, sialic acid. CH65 neutralizes infectivity of 30 out of 36 H1N1 strains tested. The resistant strains have a single-residue insertion near the rim of the sialic-acid pocket. We conclude that broad neutralization of influenza virus can be achieved by antibodies with contacts that mimic those of the receptor.
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==About this Structure==
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Broadly neutralizing human antibody that recognizes the receptor-binding pocket of influenza virus hemagglutinin.,Whittle JR, Zhang R, Khurana S, King LR, Manischewitz J, Golding H, Dormitzer PR, Haynes BF, Walter EB, Moody MA, Kepler TB, Liao HX, Harrison SC Proc Natl Acad Sci U S A. 2011 Aug 8. PMID:21825125<ref>PMID:21825125</ref>
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[[3sm5]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Influenza_a_virus Influenza a virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SM5 OCA].
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
==See Also==
==See Also==
*[[Hemagglutinin|Hemagglutinin]]
*[[Hemagglutinin|Hemagglutinin]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:021825125</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Influenza a virus]]
[[Category: Influenza a virus]]
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[[Category: Harrison, S C.]]
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[[Category: Harrison, S C]]
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[[Category: Whittle, J R.R.]]
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[[Category: Whittle, J R.R]]
[[Category: Immune system]]
[[Category: Immune system]]
[[Category: Influenza hemagglutinin]]
[[Category: Influenza hemagglutinin]]

Revision as of 08:21, 18 December 2014

Influenza hemagglutinin in complex with a neutralizing antibody

3sm5, resolution 3.19Å

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