1lpl

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{{STRUCTURE_1lpl| PDB=1lpl | SCENE= }}
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==Structural Genomics of Caenorhabditis elegans: CAP-Gly domain of F53F4.3==
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===Structural Genomics of Caenorhabditis elegans: CAP-Gly domain of F53F4.3===
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<StructureSection load='1lpl' size='340' side='right' caption='[[1lpl]], [[Resolution|resolution]] 1.77&Aring;' scene=''>
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{{ABSTRACT_PUBMED_12221106}}
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1lpl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LPL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LPL FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">F53F4.3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6239 Caenorhabditis elegans])</td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lpl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lpl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1lpl RCSB], [http://www.ebi.ac.uk/pdbsum/1lpl PDBsum], [http://www.topsan.org/Proteins/SECSG/1lpl TOPSAN]</span></td></tr>
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<table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lp/1lpl_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Cytoskeleton-associated proteins (CAPs) are involved in the organization of microtubules and transportation of vesicles and organelles along the cytoskeletal network. A conserved motif, CAP-Gly, has been identified in a number of CAPs, including CLIP-170 and dynactins. The crystal structure of the CAP-Gly domain of Caenorhabditis elegans F53F4.3 protein, solved by single wavelength sulfur-anomalous phasing, revealed a novel protein fold containing three beta-sheets. The most conserved sequence, GKNDG, is located in two consecutive sharp turns on the surface, forming the entrance to a groove. Residues in the groove are highly conserved as measured from the information content of the aligned sequences. The C-terminal tail of another molecule in the crystal is bound in this groove.
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==About this Structure==
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Crystal structure of the cytoskeleton-associated protein glycine-rich (CAP-Gly) domain.,Li S, Finley J, Liu ZJ, Qiu SH, Chen H, Luan CH, Carson M, Tsao J, Johnson D, Lin G, Zhao J, Thomas W, Nagy LA, Sha B, DeLucas LJ, Wang BC, Luo M J Biol Chem. 2002 Dec 13;277(50):48596-601. Epub 2002 Sep 7. PMID:12221106<ref>PMID:12221106</ref>
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[[1lpl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LPL OCA].
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
==See Also==
==See Also==
*[[CAP-Gly domain|CAP-Gly domain]]
*[[CAP-Gly domain|CAP-Gly domain]]
*[[CAP-Gly domain of F53F4.3|CAP-Gly domain of F53F4.3]]
*[[CAP-Gly domain of F53F4.3|CAP-Gly domain of F53F4.3]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:012221106</ref><ref group="xtra">PMID:012824319</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Caenorhabditis elegans]]
[[Category: Caenorhabditis elegans]]
[[Category: Carson, M.]]
[[Category: Carson, M.]]

Revision as of 15:55, 29 September 2014

Structural Genomics of Caenorhabditis elegans: CAP-Gly domain of F53F4.3

1lpl, resolution 1.77Å

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