We apologize for Proteopedia being slow to respond. For the past two years, a new implementation of Proteopedia has been being built. Soon, it will replace this 18-year old system. All existing content will be moved to the new system at a date that will be announced here.

2hty

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
{{STRUCTURE_2hty| PDB=2hty | SCENE= }}
+
==N1 neuraminidase==
-
===N1 neuraminidase===
+
<StructureSection load='2hty' size='340' side='right' caption='[[2hty]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
-
{{ABSTRACT_PUBMED_16915235}}
+
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[2hty]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus Influenza a virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HTY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2HTY FirstGlance]. <br>
 +
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene></td></tr>
 +
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2ht5|2ht5]], [[2ht7|2ht7]], [[2ht8|2ht8]], [[2htu|2htu]], [[2htq|2htq]], [[2htv|2htv]], [[2htr|2htr]], [[2htw|2htw]], [[2hu0|2hu0]], [[2hu4|2hu4]]</td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2hty FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hty OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2hty RCSB], [http://www.ebi.ac.uk/pdbsum/2hty PDBsum]</span></td></tr>
 +
</table>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
The worldwide spread of H5N1 avian influenza has raised concerns that this virus might acquire the ability to pass readily among humans and cause a pandemic. Two anti-influenza drugs currently being used to treat infected patients are oseltamivir (Tamiflu) and zanamivir (Relenza), both of which target the neuraminidase enzyme of the virus. Reports of the emergence of drug resistance make the development of new anti-influenza molecules a priority. Neuraminidases from influenza type A viruses form two genetically distinct groups: group-1 contains the N1 neuraminidase of the H5N1 avian virus and group-2 contains the N2 and N9 enzymes used for the structure-based design of current drugs. Here we show by X-ray crystallography that these two groups are structurally distinct. Group-1 neuraminidases contain a cavity adjacent to their active sites that closes on ligand binding. Our analysis suggests that it may be possible to exploit the size and location of the group-1 cavity to develop new anti-influenza drugs.
-
==About this Structure==
+
The structure of H5N1 avian influenza neuraminidase suggests new opportunities for drug design.,Russell RJ, Haire LF, Stevens DJ, Collins PJ, Lin YP, Blackburn GM, Hay AJ, Gamblin SJ, Skehel JJ Nature. 2006 Sep 7;443(7107):45-9. Epub 2006 Aug 16. PMID:16915235<ref>PMID:16915235</ref>
-
[[2hty]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus Influenza a virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HTY OCA].
+
 
 +
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 +
</div>
==See Also==
==See Also==
Line 10: Line 20:
*[[Eric Martz's Favorites|Eric Martz's Favorites]]
*[[Eric Martz's Favorites|Eric Martz's Favorites]]
*[[Neuraminidase|Neuraminidase]]
*[[Neuraminidase|Neuraminidase]]
-
 
+
== References ==
-
==Reference==
+
<references/>
-
<ref group="xtra">PMID:016915235</ref><references group="xtra"/>
+
__TOC__
 +
</StructureSection>
[[Category: Influenza a virus]]
[[Category: Influenza a virus]]
-
[[Category: Blackburn, G M.]]
+
[[Category: Blackburn, G M]]
-
[[Category: Collins, P J.]]
+
[[Category: Collins, P J]]
-
[[Category: Gamblin, S J.]]
+
[[Category: Gamblin, S J]]
-
[[Category: Haire, L F.]]
+
[[Category: Haire, L F]]
-
[[Category: Hay, A J.]]
+
[[Category: Hay, A J]]
-
[[Category: Lin, Y P.]]
+
[[Category: Lin, Y P]]
-
[[Category: Russell, R J.]]
+
[[Category: Russell, R J]]
-
[[Category: Skehel, J J.]]
+
[[Category: Skehel, J J]]
-
[[Category: Stevens, D J.]]
+
[[Category: Stevens, D J]]
[[Category: Hydrolase]]
[[Category: Hydrolase]]
[[Category: N1]]
[[Category: N1]]
[[Category: Neuraminidase]]
[[Category: Neuraminidase]]

Revision as of 14:09, 17 December 2014

N1 neuraminidase

2hty, resolution 2.50Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2hty"
Personal tools