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1lgl
From Proteopedia
(Difference between revisions)
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| - | + | ==Solution structure of HERG-specific scorpion toxin BeKm-1== | |
| - | + | <StructureSection load='1lgl' size='340' side='right' caption='[[1lgl]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | |
| - | + | == Structural highlights == | |
| + | <table><tr><td colspan='2'>[[1lgl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mesobuthus_eupeus Mesobuthus eupeus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LGL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LGL FirstGlance]. <br> | ||
| + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lgl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lgl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1lgl RCSB], [http://www.ebi.ac.uk/pdbsum/1lgl PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The scorpion toxin BeKm-1 is unique among a variety of known short scorpion toxins affecting potassium channels in its selective action on ether-a-go-go-related gene (ERG)-type channels. BeKm-1 shares the common molecular scaffold with other short scorpion toxins. The toxin spatial structure resolved by NMR consists of a short alpha-helix and a triple-stranded antiparallel beta-sheet. By toxin mutagenesis study we identified the residues that are important for the binding of BeKm-1 to the human ERG K+ (HERG) channel. The most critical residues (Tyr-11, Lys-18, Arg-20, Lys-23) are located in the alpha-helix and following loop whereas the "traditional" functional site of other short scorpion toxins is formed by residues from the beta-sheet. Thus the unique location of the binding site of BeKm-1 provides its specificity toward the HERG channel. | ||
| - | + | New binding site on common molecular scaffold provides HERG channel specificity of scorpion toxin BeKm-1.,Korolkova YV, Bocharov EV, Angelo K, Maslennikov IV, Grinenko OV, Lipkin AV, Nosyreva ED, Pluzhnikov KA, Olesen SP, Arseniev AS, Grishin EV J Biol Chem. 2002 Nov 8;277(45):43104-9. Epub 2002 Jul 31. PMID:12151390<ref>PMID:12151390</ref> | |
| - | + | ||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
==See Also== | ==See Also== | ||
*[[Potassium channel toxin|Potassium channel toxin]] | *[[Potassium channel toxin|Potassium channel toxin]] | ||
| - | + | == References == | |
| - | == | + | <references/> |
| - | < | + | __TOC__ |
| + | </StructureSection> | ||
[[Category: Mesobuthus eupeus]] | [[Category: Mesobuthus eupeus]] | ||
| - | [[Category: Angelo, K | + | [[Category: Angelo, K]] |
| - | [[Category: Arseniev, A S | + | [[Category: Arseniev, A S]] |
| - | [[Category: Bocharov, E V | + | [[Category: Bocharov, E V]] |
| - | [[Category: Grinenko, O V | + | [[Category: Grinenko, O V]] |
| - | [[Category: Grishin, E V | + | [[Category: Grishin, E V]] |
| - | [[Category: Korolokova, Y V | + | [[Category: Korolokova, Y V]] |
| - | [[Category: Lipkin, A V | + | [[Category: Lipkin, A V]] |
| - | [[Category: Maslennikov, I V | + | [[Category: Maslennikov, I V]] |
| - | [[Category: Nosireva, E D | + | [[Category: Nosireva, E D]] |
| - | [[Category: Olesen, S P | + | [[Category: Olesen, S P]] |
| - | [[Category: Pluzhnikov, K A | + | [[Category: Pluzhnikov, K A]] |
[[Category: Alpha-beta motif]] | [[Category: Alpha-beta motif]] | ||
[[Category: Cysteine-knot motif]] | [[Category: Cysteine-knot motif]] | ||
[[Category: Toxin]] | [[Category: Toxin]] | ||
Revision as of 13:48, 17 December 2014
Solution structure of HERG-specific scorpion toxin BeKm-1
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