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2bai

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{{STRUCTURE_2bai| PDB=2bai | SCENE= }}
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==The Zinc finger domain of Mengovirus Leader polypeptide==
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===The Zinc finger domain of Mengovirus Leader polypeptide===
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<StructureSection load='2bai' size='340' side='right' caption='[[2bai]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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{{ABSTRACT_PUBMED_18291103}}
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2bai]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mengo_virus Mengo virus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BAI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BAI FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bai FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bai OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2bai RCSB], [http://www.ebi.ac.uk/pdbsum/2bai PDBsum], [http://www.topsan.org/Proteins/CESG/2bai TOPSAN]</span></td></tr>
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<table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ba/2bai_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The Leader protein is a defining feature of picornaviruses from the Cardiovirus genus. This protein was recently shown to inhibit cellular nucleocytoplasmic transport through an activity mapped to its zinc-binding region. Here we report the three-dimensional solution structure determined by nuclear magnetic resonance (NMR) spectroscopy of this domain (residues 5-28) from mengovirus. The domain forms a CHCC zinc-finger with a fold comprising a beta-hairpin followed by a short alpha-helix that can adopt two different conformations. This structure is divergent from those of other eukaryotic zinc-fingers and instead resembles motifs found in a group of DNA-binding proteins from Archaea.
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==About this Structure==
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NMR structure of the mengovirus Leader protein zinc-finger domain.,Cornilescu CC, Porter FW, Zhao KQ, Palmenberg AC, Markley JL FEBS Lett. 2008 Mar 19;582(6):896-900. Epub 2008 Feb 20. PMID:18291103<ref>PMID:18291103</ref>
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[[2bai]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mengo_virus Mengo virus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BAI OCA].
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
==See Also==
==See Also==
*[[Zinc Fingers|Zinc Fingers]]
*[[Zinc Fingers|Zinc Fingers]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:018291103</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Mengo virus]]
[[Category: Mengo virus]]
[[Category: CESG, Center for Eukaryotic Structural Genomics.]]
[[Category: CESG, Center for Eukaryotic Structural Genomics.]]

Revision as of 00:29, 30 September 2014

The Zinc finger domain of Mengovirus Leader polypeptide

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