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3pbl

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{{STRUCTURE_3pbl| PDB=3pbl | SCENE= }}
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==Structure of the human dopamine D3 receptor in complex with eticlopride==
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===Structure of the human dopamine D3 receptor in complex with eticlopride===
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<StructureSection load='3pbl' size='340' side='right' caption='[[3pbl]], [[Resolution|resolution]] 2.89&Aring;' scene=''>
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{{ABSTRACT_PUBMED_21097933}}
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3pbl]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterobacteria_phage_t4 Enterobacteria phage t4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PBL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3PBL FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ETQ:3-CHLORO-5-ETHYL-N-{[(2S)-1-ETHYLPYRROLIDIN-2-YL]METHYL}-6-HYDROXY-2-METHOXYBENZAMIDE'>ETQ</scene>, <scene name='pdbligand=MAL:MALTOSE'>MAL</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">DRD3, E ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10665 Enterobacteria phage T4])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3pbl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pbl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3pbl RCSB], [http://www.ebi.ac.uk/pdbsum/3pbl PDBsum]</span></td></tr>
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</table>
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== Disease ==
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[[http://www.uniprot.org/uniprot/DRD3_HUMAN DRD3_HUMAN]] Hereditary essential tremor. Disease susceptibility is associated with variations affecting the gene represented in this entry.
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== Function ==
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[[http://www.uniprot.org/uniprot/DRD3_HUMAN DRD3_HUMAN]] Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Promotes cell proliferation.<ref>PMID:19520868</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Dopamine modulates movement, cognition, and emotion through activation of dopamine G protein-coupled receptors in the brain. The crystal structure of the human dopamine D3 receptor (D3R) in complex with the small molecule D2R/D3R-specific antagonist eticlopride reveals important features of the ligand binding pocket and extracellular loops. On the intracellular side of the receptor, a locked conformation of the ionic lock and two distinctly different conformations of intracellular loop 2 are observed. Docking of R-22, a D3R-selective antagonist, reveals an extracellular extension of the eticlopride binding site that comprises a second binding pocket for the aryl amide of R-22, which differs between the highly homologous D2R and D3R. This difference provides direction to the design of D3R-selective agents for treating drug abuse and other neuropsychiatric indications.
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==About this Structure==
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Structure of the human dopamine D3 receptor in complex with a D2/D3 selective antagonist.,Chien EY, Liu W, Zhao Q, Katritch V, Han GW, Hanson MA, Shi L, Newman AH, Javitch JA, Cherezov V, Stevens RC Science. 2010 Nov 19;330(6007):1091-5. PMID:21097933<ref>PMID:21097933</ref>
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[[3pbl]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterobacteria_phage_t4 Enterobacteria phage t4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PBL OCA].
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==See Also==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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*[[G protein-coupled receptor|G protein-coupled receptor]]
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</div>
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*[[Hen Egg-White (HEW) Lysozyme|Hen Egg-White (HEW) Lysozyme]]
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*[[Human dopamine d3 receptor|Human dopamine d3 receptor]]
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==Reference==
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==See Also==
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<ref group="xtra">PMID:021097933</ref><references group="xtra"/>
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*[[Dopamine receptor|Dopamine receptor]]
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*[[Lysozyme 3D structures|Lysozyme 3D structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Enterobacteria phage t4]]
[[Category: Enterobacteria phage t4]]
[[Category: Lysozyme]]
[[Category: Lysozyme]]
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[[Category: ATCG3D, Accelerated Technologies Center for Gene to 3D Structure.]]
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[[Category: ATCG3D, Accelerated Technologies Center for Gene to 3D Structure]]
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[[Category: Cherezov, V.]]
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[[Category: Cherezov, V]]
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[[Category: Chien, E Y.T.]]
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[[Category: Chien, E Y.T]]
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[[Category: GPCR, GPCR Network.]]
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[[Category: GPCR, GPCR Network]]
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[[Category: Han, G W.]]
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[[Category: Han, G W]]
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[[Category: Katritch, V.]]
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[[Category: Katritch, V]]
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[[Category: Liu, W.]]
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[[Category: Liu, W]]
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[[Category: Stevens, R C.]]
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[[Category: Stevens, R C]]
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[[Category: Zhao, Q.]]
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[[Category: Zhao, Q]]
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[[Category: 7tm]]
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[[Category: Accelerated technologies center for gene to 3d structure]]
[[Category: Accelerated technologies center for gene to 3d structure]]
[[Category: Atcg3d]]
[[Category: Atcg3d]]
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[[Category: Membrane protein]]
[[Category: Membrane protein]]
[[Category: Neurotransmitter]]
[[Category: Neurotransmitter]]
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[[Category: Protein structure initiative]]
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[[Category: PSI, Protein structure initiative]]
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[[Category: Psi-2]]
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[[Category: Psi-biology]]
[[Category: Psi-biology]]
[[Category: Signal transduction]]
[[Category: Signal transduction]]

Revision as of 06:26, 19 December 2014

Structure of the human dopamine D3 receptor in complex with eticlopride

3pbl, resolution 2.89Å

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