4e86

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{{STRUCTURE_4e86| PDB=4e86 | SCENE= }}
{{STRUCTURE_4e86| PDB=4e86 | SCENE= }}
===Crystal structure of human alpha-defensin 5, HD5 (Leu29Aba mutant)===
===Crystal structure of human alpha-defensin 5, HD5 (Leu29Aba mutant)===
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{{ABSTRACT_PUBMED_022573326}}
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{{ABSTRACT_PUBMED_22573326}}
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==Function==
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[[http://www.uniprot.org/uniprot/DEF5_HUMAN DEF5_HUMAN]] Has antimicrobial activity against Gram-negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane. All DEFA5 peptides exert antimicrobial activities, but their potency is affected by peptide processing.<ref>PMID:12021776</ref> <ref>PMID:15616305</ref> <ref>PMID:17088326</ref>
==About this Structure==
==About this Structure==
[[4e86]] is a 9 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4E86 OCA].
[[4e86]] is a 9 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4E86 OCA].
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==See Also==
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==Reference==
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*[[Defensin|Defensin]]
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<ref group="xtra">PMID:022573326</ref><references group="xtra"/><references/>
[[Category: Pazgier, M.]]
[[Category: Pazgier, M.]]
[[Category: Wu, X.]]
[[Category: Wu, X.]]

Revision as of 15:23, 19 June 2013

Template:STRUCTURE 4e86

Contents

Crystal structure of human alpha-defensin 5, HD5 (Leu29Aba mutant)

Template:ABSTRACT PUBMED 22573326

Function

[DEF5_HUMAN] Has antimicrobial activity against Gram-negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane. All DEFA5 peptides exert antimicrobial activities, but their potency is affected by peptide processing.[1] [2] [3]

About this Structure

4e86 is a 9 chain structure. Full crystallographic information is available from OCA.

Reference

  • Rajabi M, Ericksen B, Wu X, de Leeuw E, Zhao L, Pazgier M, Lu W. Functional determinants of human enteric alpha-defensin HD5: crucial role for hydrophobicity at dimer interface. J Biol Chem. 2012 Jun 22;287(26):21615-27. Epub 2012 May 9. PMID:22573326 doi:10.1074/jbc.M112.367995
  1. ↑ Ghosh D, Porter E, Shen B, Lee SK, Wilk D, Drazba J, Yadav SP, Crabb JW, Ganz T, Bevins CL. Paneth cell trypsin is the processing enzyme for human defensin-5. Nat Immunol. 2002 Jun;3(6):583-90. Epub 2002 May 20. PMID:12021776 doi:10.1038/ni797
  2. ↑ Ericksen B, Wu Z, Lu W, Lehrer RI. Antibacterial activity and specificity of the six human {alpha}-defensins. Antimicrob Agents Chemother. 2005 Jan;49(1):269-75. PMID:15616305 doi:10.1128/AAC.49.1.269-275.2005
  3. ↑ Szyk A, Wu Z, Tucker K, Yang D, Lu W, Lubkowski J. Crystal structures of human alpha-defensins HNP4, HD5, and HD6. Protein Sci. 2006 Dec;15(12):2749-60. Epub 2006 Nov 6. PMID:17088326 doi:ps.062336606

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