2az0
From Proteopedia
(Difference between revisions)
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| - | + | ==Flock House virus B2-dsRNA Complex (P212121)== | |
| - | ===Flock | + | <StructureSection load='2az0' size='340' side='right' caption='[[2az0]], [[Resolution|resolution]] 2.60Å' scene=''> |
| - | + | == Structural highlights == | |
| + | <table><tr><td colspan='2'>[[2az0]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Flock_house_virus Flock house virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AZ0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2AZ0 FirstGlance]. <br> | ||
| + | </td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=5BU:5-BROMO-URIDINE-5-MONOPHOSPHATE'>5BU</scene></td></tr> | ||
| + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2az2|2az2]]</td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">B2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=12287 Flock house virus])</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2az0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2az0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2az0 RCSB], [http://www.ebi.ac.uk/pdbsum/2az0 PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | As a counter-defense against antiviral RNA silencing during infection, the insect Flock House virus (FHV) expresses the silencing suppressor protein B2. Biochemical experiments show that B2 binds to double-stranded RNA (dsRNA) without regard to length and inhibits cleavage of dsRNA by Dicer in vitro. A cocrystal structure reveals that a B2 dimer forms a four-helix bundle that binds to one face of an A-form RNA duplex independently of sequence. These results suggest that B2 blocks both cleavage of the FHV genome by Dicer and incorporation of FHV small interfering RNAs into the RNA-induced silencing complex. | ||
| - | + | Dual modes of RNA-silencing suppression by Flock House virus protein B2.,Chao JA, Lee JH, Chapados BR, Debler EW, Schneemann A, Williamson JR Nat Struct Mol Biol. 2005 Nov;12(11):952-7. PMID:16228003<ref>PMID:16228003</ref> | |
| - | + | ||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
==See Also== | ==See Also== | ||
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*[[User:Wayne Decatur/Suppression of RNA Silencing by Viruses|User:Wayne Decatur/Suppression of RNA Silencing by Viruses]] | *[[User:Wayne Decatur/Suppression of RNA Silencing by Viruses|User:Wayne Decatur/Suppression of RNA Silencing by Viruses]] | ||
*[[User:Wayne Decatur/Tomato aspermy virus protein 2b Suppression of RNA Silencing|User:Wayne Decatur/Tomato aspermy virus protein 2b Suppression of RNA Silencing]] | *[[User:Wayne Decatur/Tomato aspermy virus protein 2b Suppression of RNA Silencing|User:Wayne Decatur/Tomato aspermy virus protein 2b Suppression of RNA Silencing]] | ||
| - | + | == References == | |
| - | == | + | <references/> |
| - | < | + | __TOC__ |
| + | </StructureSection> | ||
[[Category: Flock house virus]] | [[Category: Flock house virus]] | ||
| - | [[Category: Chao, J A | + | [[Category: Chao, J A]] |
| - | [[Category: Chapados, B R | + | [[Category: Chapados, B R]] |
| - | [[Category: Debler, E W | + | [[Category: Debler, E W]] |
| - | [[Category: Lee, J H | + | [[Category: Lee, J H]] |
| - | [[Category: Schneemann, A | + | [[Category: Schneemann, A]] |
| - | [[Category: Williamson, J R | + | [[Category: Williamson, J R]] |
[[Category: Four-helix bundle]] | [[Category: Four-helix bundle]] | ||
[[Category: Protein-rna complex]] | [[Category: Protein-rna complex]] | ||
[[Category: Viral protein-rna complex]] | [[Category: Viral protein-rna complex]] | ||
Revision as of 14:16, 17 December 2014
Flock House virus B2-dsRNA Complex (P212121)
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