4a7f

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{{STRUCTURE_4a7f| PDB=4a7f | SCENE= }}
 
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===Structure of the Actin-Tropomyosin-Myosin Complex (rigor ATM 3)===
 
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{{ABSTRACT_PUBMED_22817895}}
 
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==About this Structure==
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==Structure of the Actin-Tropomyosin-Myosin Complex (rigor ATM 3)==
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[[4a7f]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Dictyostelium_discoideum Dictyostelium discoideum] and [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A7F OCA].
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<StructureSection load='4a7f' size='340' side='right' caption='[[4a7f]], [[Resolution|resolution]] 7.70&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4a7f]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_11735 Atcc 11735], [http://en.wikipedia.org/wiki/European_rabbit European rabbit] and [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A7F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4A7F FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=HIC:4-METHYL-HISTIDINE'>HIC</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1alm|1alm]], [[1atn|1atn]], [[1eqy|1eqy]], [[1esv|1esv]], [[1h1v|1h1v]], [[1ijj|1ijj]], [[1j6z|1j6z]], [[1kxp|1kxp]], [[1lcu|1lcu]], [[1lkx|1lkx]], [[1lot|1lot]], [[1m8q|1m8q]], [[1ma9|1ma9]], [[1mvw|1mvw]], [[1nwk|1nwk]], [[1o18|1o18]], [[1o19|1o19]], [[1o1a|1o1a]], [[1o1b|1o1b]], [[1o1c|1o1c]], [[1o1d|1o1d]], [[1o1e|1o1e]], [[1o1f|1o1f]], [[1o1g|1o1g]], [[1p8z|1p8z]], [[1qz5|1qz5]], [[1qz6|1qz6]], [[1rdw|1rdw]], [[1rfq|1rfq]], [[1rgi|1rgi]], [[1s22|1s22]], [[1sqk|1sqk]], [[1t44|1t44]], [[1uy5|1uy5]], [[1wua|1wua]], [[1y64|1y64]], [[2a3z|2a3z]], [[2a40|2a40]], [[2a41|2a41]], [[2a42|2a42]], [[2a5x|2a5x]], [[2asm|2asm]], [[2aso|2aso]], [[2asp|2asp]], [[2d1k|2d1k]], [[2d3e|2d3e]], [[2ff3|2ff3]], [[2ff6|2ff6]], [[2fxu|2fxu]], [[2tma|2tma]], [[2v51|2v51]], [[2v52|2v52]], [[2vcp|2vcp]], [[2vyp|2vyp]], [[2w49|2w49]], [[2w4u|2w4u]], [[2y83|2y83]], [[2yje|2yje]], [[2yjf|2yjf]], [[4a7h|4a7h]], [[4a7l|4a7l]], [[4a7n|4a7n]]</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Myosin_ATPase Myosin ATPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.4.1 3.6.4.1] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4a7f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a7f OCA], [http://pdbe.org/4a7f PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4a7f RCSB], [http://www.ebi.ac.uk/pdbsum/4a7f PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4a7f ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/ACTS_RABIT ACTS_RABIT]] Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. [[http://www.uniprot.org/uniprot/MYOE_DICDI MYOE_DICDI]] Myosin is a protein that binds to actin and has ATPase activity that is activated by actin. May play a role in moving membranes relative to actin. [[http://www.uniprot.org/uniprot/TPM1_RABIT TPM1_RABIT]] Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments.
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Regulation of myosin and filamentous actin interaction by tropomyosin is a central feature of contractile events in muscle and nonmuscle cells. However, little is known about molecular interactions within the complex and the trajectory of tropomyosin movement between its "open" and "closed" positions on the actin filament. Here, we report the 8 A resolution structure of the rigor (nucleotide-free) actin-tropomyosin-myosin complex determined by cryo-electron microscopy. The pseudoatomic model of the complex, obtained from fitting crystal structures into the map, defines the large interface involving two adjacent actin monomers and one tropomyosin pseudorepeat per myosin contact. Severe forms of hereditary myopathies are linked to mutations that critically perturb this interface. Myosin binding results in a 23 A shift of tropomyosin along actin. Complex domain motions occur in myosin, but not in actin. Based on our results, we propose a structural model for the tropomyosin-dependent modulation of myosin binding to actin.
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Structure of the rigor actin-tropomyosin-Myosin complex.,Behrmann E, Muller M, Penczek PA, Mannherz HG, Manstein DJ, Raunser S Cell. 2012 Jul 20;150(2):327-38. PMID:22817895<ref>PMID:22817895</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 4a7f" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
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*[[Myosin|Myosin]]
*[[Myosin|Myosin]]
*[[Tropomyosin|Tropomyosin]]
*[[Tropomyosin|Tropomyosin]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:022817895</ref><references group="xtra"/>
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__TOC__
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[[Category: Dictyostelium discoideum]]
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</StructureSection>
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[[Category: Atcc 11735]]
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[[Category: European rabbit]]
[[Category: Myosin ATPase]]
[[Category: Myosin ATPase]]
[[Category: Oryctolagus cuniculus]]
[[Category: Oryctolagus cuniculus]]
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[[Category: Behrmann, E.]]
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[[Category: Behrmann, E]]
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[[Category: Mannherz, H G.]]
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[[Category: Mannherz, H G]]
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[[Category: Manstein, D J.]]
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[[Category: Manstein, D J]]
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[[Category: Mueller, M.]]
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[[Category: Mueller, M]]
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[[Category: Penczek, P A.]]
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[[Category: Penczek, P A]]
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[[Category: Raunser, S.]]
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[[Category: Raunser, S]]
[[Category: Actin binding]]
[[Category: Actin binding]]
[[Category: Atp catabolic process]]
[[Category: Atp catabolic process]]

Revision as of 05:17, 5 August 2016

Structure of the Actin-Tropomyosin-Myosin Complex (rigor ATM 3)

4a7f, resolution 7.70Å

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