2bj6

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[[Image:2bj6.gif|left|200px]]<br /><applet load="2bj6" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:2bj6.gif|left|200px]]
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caption="2bj6, resolution 2.60&Aring;" />
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'''CRYSTAL STRUCTURE OF A DECAMERIC HNA-RNA HYBRID'''<br />
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{{Structure
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|PDB= 2bj6 |SIZE=350|CAPTION= <scene name='initialview01'>2bj6</scene>, resolution 2.60&Aring;
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|SITE= <scene name='pdbsite=AC1:So4+Binding+Site+For+Chain+G'>AC1</scene>
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|LIGAND= <scene name='pdbligand=SO4:SULFATE ION'>SO4</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''CRYSTAL STRUCTURE OF A DECAMERIC HNA-RNA HYBRID'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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2BJ6 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/ ] with <scene name='pdbligand=SO4:'>SO4</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Known structural/functional Site: <scene name='pdbsite=AC1:So4+Binding+Site+For+Chain+G'>AC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BJ6 OCA].
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2BJ6 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BJ6 OCA].
==Reference==
==Reference==
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Reinforced HNA backbone hydration in the crystal structure of a decameric HNA/RNA hybrid., Maier T, Przylas I, Strater N, Herdewijn P, Saenger W, J Am Chem Soc. 2005 Mar 9;127(9):2937-43. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15740130 15740130]
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Reinforced HNA backbone hydration in the crystal structure of a decameric HNA/RNA hybrid., Maier T, Przylas I, Strater N, Herdewijn P, Saenger W, J Am Chem Soc. 2005 Mar 9;127(9):2937-43. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15740130 15740130]
[[Category: Single protein]]
[[Category: Single protein]]
[[Category: Herdewijn, P.]]
[[Category: Herdewijn, P.]]
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[[Category: rna]]
[[Category: rna]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:38:26 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 16:02:37 2008''

Revision as of 14:02, 20 March 2008

Image:2bj6.gif


PDB ID 2bj6

Drag the structure with the mouse to rotate
, resolution 2.60Å
Sites:
Ligands:
Coordinates: save as pdb, mmCIF, xml



CRYSTAL STRUCTURE OF A DECAMERIC HNA-RNA HYBRID


Overview

The crystal structure of a decameric HNA/RNA (HNA = 2',3'-dideoxy-1',5'-anhydro-d-arabinohexitol nucleic acid) hybrid with the RNA sequence 5'-GGCAUUACGG-3' is the first crystal structure of a hybrid duplex between a naturally occurring nucleic acid and a strand, which is fully modified to contain a six-membered ring instead of ribose. The presence of four duplex helices in the asymmetric unit allows for a detailed discussion of hydration, which revealed a tighter spinelike backbone hydration for the HNA- than for the RNA-strands. The reinforced backbone hydration is suggested to contribute significantly to the exceptional stability of HNA-containing duplexes and might be one of the causes for the evolutionary preference for ribose-derived nucleic acids.

About this Structure

2BJ6 is a Single protein structure of sequence from [1]. Full crystallographic information is available from OCA.

Reference

Reinforced HNA backbone hydration in the crystal structure of a decameric HNA/RNA hybrid., Maier T, Przylas I, Strater N, Herdewijn P, Saenger W, J Am Chem Soc. 2005 Mar 9;127(9):2937-43. PMID:15740130

Page seeded by OCA on Thu Mar 20 16:02:37 2008

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