2bkd
From Proteopedia
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| - | [[Image:2bkd.gif|left|200px]] | + | [[Image:2bkd.gif|left|200px]] |
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| - | '''STRUCTURE OF THE N-TERMINAL DOMAIN OF FRAGILE X MENTAL RETARDATION PROTEIN''' | + | {{Structure |
| + | |PDB= 2bkd |SIZE=350|CAPTION= <scene name='initialview01'>2bkd</scene> | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
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| + | '''STRUCTURE OF THE N-TERMINAL DOMAIN OF FRAGILE X MENTAL RETARDATION PROTEIN''' | ||
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==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2BKD is a [ | + | 2BKD is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BKD OCA]. |
==Reference== | ==Reference== | ||
| - | The structure of the N-terminal domain of the fragile X mental retardation protein: a platform for protein-protein interaction., Ramos A, Hollingworth D, Adinolfi S, Castets M, Kelly G, Frenkiel TA, Bardoni B, Pastore A, Structure. 2006 Jan;14(1):21-31. PMID:[http:// | + | The structure of the N-terminal domain of the fragile X mental retardation protein: a platform for protein-protein interaction., Ramos A, Hollingworth D, Adinolfi S, Castets M, Kelly G, Frenkiel TA, Bardoni B, Pastore A, Structure. 2006 Jan;14(1):21-31. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16407062 16407062] |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: protein-protein interaction]] | [[Category: protein-protein interaction]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 16:03:04 2008'' |
Revision as of 14:03, 20 March 2008
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STRUCTURE OF THE N-TERMINAL DOMAIN OF FRAGILE X MENTAL RETARDATION PROTEIN
Contents |
Overview
FMRP, whose lack of expression causes the X-linked fragile X syndrome, is a modular RNA binding protein thought to be involved in posttranslational regulation. We have solved the structure in solution of the N-terminal domain of FMRP (NDF), a functionally important region involved in multiple interactions. The structure consists of a composite fold comprising two repeats of a Tudor motif followed by a short alpha helix. The interactions between the three structural elements are essential for the stability of the NDF fold. Although structurally similar, the two repeats have different dynamic and functional properties. The second, more flexible repeat is responsible for interacting both with methylated lysine and with 82-FIP, one of the FMRP nuclear partners. NDF contains a 3D nucleolar localization signal, since destabilization of its fold leads to altered nucleolar localization of FMRP. We suggest that the NDF composite fold determines an allosteric mechanism that regulates the FMRP functions.
Disease
Known diseases associated with this structure: Fragile X syndrome OMIM:[309550], Fragile X tremor/ataxia syndrome OMIM:[309550]
About this Structure
2BKD is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
The structure of the N-terminal domain of the fragile X mental retardation protein: a platform for protein-protein interaction., Ramos A, Hollingworth D, Adinolfi S, Castets M, Kelly G, Frenkiel TA, Bardoni B, Pastore A, Structure. 2006 Jan;14(1):21-31. PMID:16407062
Page seeded by OCA on Thu Mar 20 16:03:04 2008
