2bkt

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[[Image:2bkt.gif|left|200px]]<br /><applet load="2bkt" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:2bkt.gif|left|200px]]
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caption="2bkt, resolution 2.3&Aring;" />
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'''CRYSTAL STRUCTURE OF RENIN-PF00257567 COMPLEX'''<br />
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{{Structure
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|PDB= 2bkt |SIZE=350|CAPTION= <scene name='initialview01'>2bkt</scene>, resolution 2.3&Aring;
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|SITE= <scene name='pdbsite=AC1:Rpf+Binding+Site+For+Chain+B'>AC1</scene>
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|LIGAND= <scene name='pdbligand=RPF:1-{4-[3-(2-METHOXY-BENZYLOXY)-PROPOXY]-PHENYL}-6-(1,2,,3,4-TETRAHYDRO-QUINOLIN-7-YLOXYMETHYL)-PIPERAZIN-2-ONE'>RPF</scene>
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|ACTIVITY= [http://en.wikipedia.org/wiki/Renin Renin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.15 3.4.23.15]
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|GENE=
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}}
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'''CRYSTAL STRUCTURE OF RENIN-PF00257567 COMPLEX'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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2BKT is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=RPF:'>RPF</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Renin Renin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.15 3.4.23.15] Known structural/functional Site: <scene name='pdbsite=AC1:Rpf+Binding+Site+For+Chain+B'>AC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BKT OCA].
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2BKT is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BKT OCA].
==Reference==
==Reference==
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Equipotent activity in both enantiomers of a series of ketopiperazine-based renin inhibitors., Powell NA, Clay EH, Holsworth DD, Bryant JW, Ryan MJ, Jalaie M, Zhang E, Edmunds JJ, Bioorg Med Chem Lett. 2005 May 2;15(9):2371-4. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15837327 15837327]
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Equipotent activity in both enantiomers of a series of ketopiperazine-based renin inhibitors., Powell NA, Clay EH, Holsworth DD, Bryant JW, Ryan MJ, Jalaie M, Zhang E, Edmunds JJ, Bioorg Med Chem Lett. 2005 May 2;15(9):2371-4. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15837327 15837327]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Renin]]
[[Category: Renin]]
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[[Category: renin]]
[[Category: renin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:38:52 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 16:03:15 2008''

Revision as of 14:03, 20 March 2008

Image:2bkt.gif


PDB ID 2bkt

Drag the structure with the mouse to rotate
, resolution 2.3Å
Sites:
Ligands:
Activity: Renin, with EC number 3.4.23.15
Coordinates: save as pdb, mmCIF, xml



CRYSTAL STRUCTURE OF RENIN-PF00257567 COMPLEX


Contents

Overview

We have found that both enantiomeric configurations of the 6-alkoxymethyl-1-aryl-2-piperazinone scaffold display equipotent renin inhibition activity and similar SAR patterns. This enantiomeric flexibility is in contrast to a previously reported 3-alkoxymethyl-4-arylpiperidine scaffold.

Disease

Known diseases associated with this structure: Hyperproreninemia OMIM:[179820], Renal tubular dysgenesis OMIM:[179820]

About this Structure

2BKT is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Equipotent activity in both enantiomers of a series of ketopiperazine-based renin inhibitors., Powell NA, Clay EH, Holsworth DD, Bryant JW, Ryan MJ, Jalaie M, Zhang E, Edmunds JJ, Bioorg Med Chem Lett. 2005 May 2;15(9):2371-4. PMID:15837327

Page seeded by OCA on Thu Mar 20 16:03:15 2008

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