4ikn
From Proteopedia
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===Crystal structure of adaptor protein complex 3 (AP-3) mu3A subunit C-terminal domain, in complex with a sorting peptide from TGN38=== | ===Crystal structure of adaptor protein complex 3 (AP-3) mu3A subunit C-terminal domain, in complex with a sorting peptide from TGN38=== | ||
{{ABSTRACT_PUBMED_23404500}} | {{ABSTRACT_PUBMED_23404500}} | ||
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| + | ==Function== | ||
| + | [[http://www.uniprot.org/uniprot/AP3M1_RAT AP3M1_RAT]] Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals (By similarity). | ||
==About this Structure== | ==About this Structure== | ||
[[4ikn]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IKN OCA]. | [[4ikn]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IKN OCA]. | ||
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| + | ==Reference== | ||
| + | <ref group="xtra">PMID:023404500</ref><references group="xtra"/><references/> | ||
[[Category: Rattus norvegicus]] | [[Category: Rattus norvegicus]] | ||
[[Category: Bonifacino, J S.]] | [[Category: Bonifacino, J S.]] | ||
Revision as of 05:42, 28 August 2013
Contents |
Crystal structure of adaptor protein complex 3 (AP-3) mu3A subunit C-terminal domain, in complex with a sorting peptide from TGN38
Template:ABSTRACT PUBMED 23404500
Function
[AP3M1_RAT] Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals (By similarity).
About this Structure
4ikn is a 2 chain structure with sequence from Rattus norvegicus. Full crystallographic information is available from OCA.
Reference
- Mardones GA, Burgos PV, Lin Y, Kloer DP, Magadan JG, Hurley JH, Bonifacino JS. Structural Basis for the Recognition of Tyrosine-based Sorting Signals by the Mu3A Subunit of the AP-3 Adaptor Complex. J Biol Chem. 2013 Feb 12. PMID:23404500 doi:10.1074/jbc.M113.450775
