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4iku

From Proteopedia

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'''Unreleased structure'''
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{{STRUCTURE_4iku| PDB=4iku | SCENE= }}
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===Crystal structure of truncated (delta 1-89) human methionine aminopeptidase Type 1 in complex with 2-((5-chloro-6-methyl-2-(pyridin-2-yl)pyrimidin-4-yl)amino)-3-phenylpropanamide===
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{{ABSTRACT_PUBMED_23767698}}
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The entry 4iku is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/AMPM1_HUMAN AMPM1_HUMAN]] Removes the N-terminal methionine from nascent proteins. Required for normal progression through the cell cycle.<ref>PMID:16274222</ref> <ref>PMID:17114291</ref>
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Authors: Addlagatta, A., Kishor, C., Arya, T.
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==About this Structure==
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[[4iku]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IKU OCA].
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Description: Crystal structure of truncated (delta 1-89) human methionine aminopeptidase Type 1 in complex with 2-((5-chloro-6-methyl-2-(pyridin-2-yl)pyrimidin-4-yl)amino)-3-phenylpropanamide
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==Reference==
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<ref group="xtra">PMID:023767698</ref><references group="xtra"/><references/>
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[[Category: Methionyl aminopeptidase]]
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[[Category: Addlagatta, A.]]
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[[Category: Arya, T.]]
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[[Category: Kishor, C.]]
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[[Category: Aminopeptidase]]
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[[Category: Hydrolase]]
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[[Category: Pita-bread fold]]
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[[Category: Ribosome]]

Revision as of 13:39, 11 December 2013

Template:STRUCTURE 4iku

Contents

Crystal structure of truncated (delta 1-89) human methionine aminopeptidase Type 1 in complex with 2-((5-chloro-6-methyl-2-(pyridin-2-yl)pyrimidin-4-yl)amino)-3-phenylpropanamide

Template:ABSTRACT PUBMED 23767698

Function

[AMPM1_HUMAN] Removes the N-terminal methionine from nascent proteins. Required for normal progression through the cell cycle.[1] [2]

About this Structure

4iku is a 1 chain structure. Full crystallographic information is available from OCA.

Reference

  • Kishor C, Arya T, Reddi R, Chen X, Saddanapu V, Marapaka AK, Gumpena R, Ma D, Liu JO, Addlagatta A. Identification, Biochemical and Structural Evaluation of Species-Specific Inhibitors against Type I Methionine Aminopeptidases. J Med Chem. 2013 Jun 27. PMID:23767698 doi:http://dx.doi.org/10.1021/jm400395p
  1. ↑ Addlagatta A, Hu X, Liu JO, Matthews BW. Structural basis for the functional differences between type I and type II human methionine aminopeptidases. Biochemistry. 2005 Nov 15;44(45):14741-9. PMID:16274222 doi:10.1021/bi051691k
  2. ↑ Hu X, Addlagatta A, Lu J, Matthews BW, Liu JO. Elucidation of the function of type 1 human methionine aminopeptidase during cell cycle progression. Proc Natl Acad Sci U S A. 2006 Nov 28;103(48):18148-53. Epub 2006 Nov 17. PMID:17114291

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