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4j24
From Proteopedia
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===Estrogen Receptor in complex with proline-flanked LXXLL peptides=== | ===Estrogen Receptor in complex with proline-flanked LXXLL peptides=== | ||
{{ABSTRACT_PUBMED_23437920}} | {{ABSTRACT_PUBMED_23437920}} | ||
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| + | ==Function== | ||
| + | [[http://www.uniprot.org/uniprot/ESR2_HUMAN ESR2_HUMAN]] Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. Isoform beta-cx lacks ligand binding ability and has no or only very low ere binding activity resulting in the loss of ligand-dependent transactivation ability. DNA-binding by ESR1 and ESR2 is rapidly lost at 37 degrees Celsius in the absence of ligand while in the presence of 17 beta-estradiol and 4-hydroxy-tamoxifen loss in DNA-binding at elevated temperature is more gradual. | ||
==About this Structure== | ==About this Structure== | ||
[[4j24]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J24 OCA]. | [[4j24]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J24 OCA]. | ||
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| + | ==Reference== | ||
| + | <ref group="xtra">PMID:023437920</ref><references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Agten, S.]] | [[Category: Agten, S.]] | ||
Revision as of 14:22, 10 July 2013
Contents |
Estrogen Receptor in complex with proline-flanked LXXLL peptides
Template:ABSTRACT PUBMED 23437920
Function
[ESR2_HUMAN] Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. Isoform beta-cx lacks ligand binding ability and has no or only very low ere binding activity resulting in the loss of ligand-dependent transactivation ability. DNA-binding by ESR1 and ESR2 is rapidly lost at 37 degrees Celsius in the absence of ligand while in the presence of 17 beta-estradiol and 4-hydroxy-tamoxifen loss in DNA-binding at elevated temperature is more gradual.
About this Structure
4j24 is a 8 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Fuchs S, Nguyen HD, Phan TT, Burton MF, Nieto L, de Vries-van Leeuwen IJ, Schmidt A, Goodarzifard M, Agten SM, Rose R, Ottmann C, Milroy LG, Brunsveld L. Proline Primed Helix Length as a Modulator of the Nuclear Receptor-Coactivator Interaction. J Am Chem Soc. 2013 Mar 7. PMID:23437920 doi:10.1021/ja311748r
Categories: Homo sapiens | Agten, S. | Brunsveld, L. | Burton, M. | Fuchs, S. | Goodarzifard, M. | Leeuwen, I de Vries-van. | Milroy, L G. | Nguyen, H D. | Nieto, L. | Ottmann, C. | Phan, T. | Rose, R. | Schmidt, A. | Alpha-helix | Estrogen receptor | Hormone receptor-peptide complex | Lxxll | Proline | Structure stabilization
