4j24

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 2: Line 2:
===Estrogen Receptor in complex with proline-flanked LXXLL peptides===
===Estrogen Receptor in complex with proline-flanked LXXLL peptides===
{{ABSTRACT_PUBMED_23437920}}
{{ABSTRACT_PUBMED_23437920}}
 +
 +
==Function==
 +
[[http://www.uniprot.org/uniprot/ESR2_HUMAN ESR2_HUMAN]] Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. Isoform beta-cx lacks ligand binding ability and has no or only very low ere binding activity resulting in the loss of ligand-dependent transactivation ability. DNA-binding by ESR1 and ESR2 is rapidly lost at 37 degrees Celsius in the absence of ligand while in the presence of 17 beta-estradiol and 4-hydroxy-tamoxifen loss in DNA-binding at elevated temperature is more gradual.
==About this Structure==
==About this Structure==
[[4j24]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J24 OCA].
[[4j24]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J24 OCA].
 +
 +
==Reference==
 +
<ref group="xtra">PMID:023437920</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Agten, S.]]
[[Category: Agten, S.]]

Revision as of 14:22, 10 July 2013

Template:STRUCTURE 4j24

Contents

Estrogen Receptor in complex with proline-flanked LXXLL peptides

Template:ABSTRACT PUBMED 23437920

Function

[ESR2_HUMAN] Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. Isoform beta-cx lacks ligand binding ability and has no or only very low ere binding activity resulting in the loss of ligand-dependent transactivation ability. DNA-binding by ESR1 and ESR2 is rapidly lost at 37 degrees Celsius in the absence of ligand while in the presence of 17 beta-estradiol and 4-hydroxy-tamoxifen loss in DNA-binding at elevated temperature is more gradual.

About this Structure

4j24 is a 8 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Fuchs S, Nguyen HD, Phan TT, Burton MF, Nieto L, de Vries-van Leeuwen IJ, Schmidt A, Goodarzifard M, Agten SM, Rose R, Ottmann C, Milroy LG, Brunsveld L. Proline Primed Helix Length as a Modulator of the Nuclear Receptor-Coactivator Interaction. J Am Chem Soc. 2013 Mar 7. PMID:23437920 doi:10.1021/ja311748r

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4j24"
Personal tools