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3id6

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===Crystal structure of Sulfolobus solfataricus Nop5 (1-262) and fibrillarin complex===
===Crystal structure of Sulfolobus solfataricus Nop5 (1-262) and fibrillarin complex===
{{ABSTRACT_PUBMED_19666563}}
{{ABSTRACT_PUBMED_19666563}}
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==Function==
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[[http://www.uniprot.org/uniprot/FLPA_SULSO FLPA_SULSO]] Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA.<ref>PMID:11959980</ref> <ref>PMID:15522081</ref>
==About this Structure==
==About this Structure==
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[[3id6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Sulfolobus_solfataricus Sulfolobus solfataricus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ID6 OCA].
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[[3id6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_35091 Atcc 35091]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ID6 OCA].
==Reference==
==Reference==
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<ref group="xtra">PMID:019666563</ref><references group="xtra"/>
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<ref group="xtra">PMID:019666563</ref><references group="xtra"/><references/>
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[[Category: Sulfolobus solfataricus]]
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[[Category: Atcc 35091]]
[[Category: Ye, K.]]
[[Category: Ye, K.]]
[[Category: 2'-o-methylation]]
[[Category: 2'-o-methylation]]

Revision as of 11:35, 20 November 2013

Template:STRUCTURE 3id6

Contents

Crystal structure of Sulfolobus solfataricus Nop5 (1-262) and fibrillarin complex

Template:ABSTRACT PUBMED 19666563

Function

[FLPA_SULSO] Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA.[1] [2]

About this Structure

3id6 is a 2 chain structure with sequence from Atcc 35091. Full crystallographic information is available from OCA.

Reference

  • Ye K, Jia R, Lin J, Ju M, Peng J, Xu A, Zhang L. Structural organization of box C/D RNA-guided RNA methyltransferase. Proc Natl Acad Sci U S A. 2009 Aug 5. PMID:19666563
  1. ↑ Omer AD, Ziesche S, Ebhardt H, Dennis PP. In vitro reconstitution and activity of a C/D box methylation guide ribonucleoprotein complex. Proc Natl Acad Sci U S A. 2002 Apr 16;99(8):5289-94. PMID:11959980 doi:http://dx.doi.org/10.1073/pnas.082101999
  2. ↑ Ziesche SM, Omer AD, Dennis PP. RNA-guided nucleotide modification of ribosomal and non-ribosomal RNAs in Archaea. Mol Microbiol. 2004 Nov;54(4):980-93. PMID:15522081 doi:http://dx.doi.org/MMI4319

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