2kgu
From Proteopedia
(Difference between revisions)
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| - | + | ==Spatial structure of purotoxin-1 in water== | |
| - | + | <StructureSection load='2kgu' size='340' side='right' caption='[[2kgu]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | |
| - | + | == Structural highlights == | |
| + | <table><tr><td colspan='2'>[[2kgu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Geolycosa Geolycosa]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KGU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KGU FirstGlance]. <br> | ||
| + | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">320151 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=176692 Geolycosa])</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kgu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kgu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2kgu RCSB], [http://www.ebi.ac.uk/pdbsum/2kgu PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | P2X3 purinoreceptors expressed in mammalian sensory neurons play a key role in several processes, including pain perception. From the venom of the Central Asian spider Geolycosa sp., we have isolated a novel peptide, named purotoxin-1 (PT1), which is to our knowledge the first natural molecule exerting powerful and selective inhibitory action on P2X3 receptors. PT1 dramatically slows down the removal of desensitization of these receptors. The peptide demonstrates potent antinociceptive properties in animal models of inflammatory pain. | ||
| - | + | Novel peptide from spider venom inhibits P2X3 receptors and inflammatory pain.,Grishin EV, Savchenko GA, Vassilevski AA, Korolkova YV, Boychuk YA, Viatchenko-Karpinski VY, Nadezhdin KD, Arseniev AS, Pluzhnikov KA, Kulyk VB, Voitenko NV, Krishtal OO Ann Neurol. 2010 May;67(5):680-3. PMID:20437566<ref>PMID:20437566</ref> | |
| - | + | ||
| - | == | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
| - | < | + | </div> |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Geolycosa]] | [[Category: Geolycosa]] | ||
| - | [[Category: Arseniev, A | + | [[Category: Arseniev, A]] |
| - | [[Category: Grishin, E | + | [[Category: Grishin, E]] |
| - | [[Category: Korolkova, Y | + | [[Category: Korolkova, Y]] |
| - | [[Category: Nadezhdin, K | + | [[Category: Nadezhdin, K]] |
| - | [[Category: Pluzhnikov, K | + | [[Category: Pluzhnikov, K]] |
| - | [[Category: Vassilevski, A | + | [[Category: Vassilevski, A]] |
[[Category: P2x receptor]] | [[Category: P2x receptor]] | ||
[[Category: Purotoxin-1]] | [[Category: Purotoxin-1]] | ||
[[Category: Toxin]] | [[Category: Toxin]] | ||
Revision as of 13:49, 17 December 2014
Spatial structure of purotoxin-1 in water
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