2brs
From Proteopedia
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| - | [[Image:2brs.jpg|left|200px]] | + | [[Image:2brs.jpg|left|200px]] |
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| - | '''EMBP HEPARIN COMPLEX''' | + | {{Structure |
| + | |PDB= 2brs |SIZE=350|CAPTION= <scene name='initialview01'>2brs</scene>, resolution 2.20Å | ||
| + | |SITE= <scene name='pdbsite=AC1:Sgn+Binding+Site+For+Chain+A'>AC1</scene> | ||
| + | |LIGAND= <scene name='pdbligand=SO4:SULFATE ION'>SO4</scene> | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
| + | |||
| + | '''EMBP HEPARIN COMPLEX''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2BRS is a [ | + | 2BRS is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BRS OCA]. |
==Reference== | ==Reference== | ||
| - | Eosinophil-granule major basic protein, a C-type lectin, binds heparin., Swaminathan GJ, Myszka DG, Katsamba PS, Ohnuki LE, Gleich GJ, Acharya KR, Biochemistry. 2005 Nov 1;44(43):14152-8. PMID:[http:// | + | Eosinophil-granule major basic protein, a C-type lectin, binds heparin., Swaminathan GJ, Myszka DG, Katsamba PS, Ohnuki LE, Gleich GJ, Acharya KR, Biochemistry. 2005 Nov 1;44(43):14152-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16245931 16245931] |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: signal]] | [[Category: signal]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 16:05:51 2008'' |
Revision as of 14:05, 20 March 2008
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| , resolution 2.20Å | |||||||
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| Sites: | |||||||
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| Coordinates: | save as pdb, mmCIF, xml | ||||||
EMBP HEPARIN COMPLEX
Contents |
Overview
The eosinophil major basic protein (EMBP), a constituent of the eosinophil secondary granule, is implicated in cytotoxicity and mediation of allergic disorders such as asthma. It is a member of the C-type lectin family, but lacks a Ca(2+)- and carbohydrate-binding site as seen in other members of this family. Here, we report the crystal structure of EMBP in complex with a heparin disaccharide and in the absence of Ca(2+), the first such report of any C-lectin with this sugar. We also provide direct evidence of binding of EMBP to heparin and heparin disaccharide by surface plasmon resonance. We propose that the sugars recognized by EMBP are likely to be proteoglycans such as heparin, leading to new interpretations for EMBP function.
Disease
Known diseases associated with this structure: Chronic infections, due to MBL deficiency OMIM:[154545], Diabetes mellitus, gestational, susceptibility to OMIM:[154545], Mannose-binding protein deficiency OMIM:[154545], Meningococcal disease, susceptibility to OMIM:[154545]
About this Structure
2BRS is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Eosinophil-granule major basic protein, a C-type lectin, binds heparin., Swaminathan GJ, Myszka DG, Katsamba PS, Ohnuki LE, Gleich GJ, Acharya KR, Biochemistry. 2005 Nov 1;44(43):14152-8. PMID:16245931
Page seeded by OCA on Thu Mar 20 16:05:51 2008
Categories: Homo sapiens | Single protein | Acharya, K R. | Gleich, G J. | Katsamba, P S. | Myszka, D G. | Ohnuki, L E. | Swaminathan, G J. | SO4 | Antibiotic | Embp | Eosinophil | Eosinophil granule protein | Glycoprotein | Heparin | Heparin-binding | Immune response | Lectin | Proteoglycan | Signal
