3i57

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{{STRUCTURE_3i57| PDB=3i57 | SCENE= }}
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==Type 2 repeat of the mucus binding protein MUB from Lactobacillus reuteri==
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===Type 2 repeat of the mucus binding protein MUB from Lactobacillus reuteri===
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<StructureSection load='3i57' size='340' side='right' caption='[[3i57]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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{{ABSTRACT_PUBMED_19758995}}
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3i57]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lactobacillus_reuteri Lactobacillus reuteri]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I57 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3I57 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">mub ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1598 Lactobacillus reuteri])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3i57 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3i57 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3i57 RCSB], [http://www.ebi.ac.uk/pdbsum/3i57 PDBsum]</span></td></tr>
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</table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i5/3i57_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Lactobacillus reuteri mucus-binding protein (MUB) is a cell-surface protein that is involved in bacterial interaction with mucus and colonization of the digestive tract. The 353-kDa mature protein is representative of a broadly important class of adhesins that have remained relatively poorly characterized due to their large size and highly modular nature. MUB contains two different types of repeats (Mub1 and Mub2) present in six and eight copies, respectively, and shown to be responsible for the adherence to intestinal mucus. Here we report the 1.8-A resolution crystal structure of a type 2 Mub repeat (184 amino acids) comprising two structurally related domains resembling the functional repeat found in a family of immunoglobulin (Ig)-binding proteins. The N-terminal domain bears striking structural similarity to the repeat unit of Protein L (PpL) from Peptostreptococcus magnus, suggesting binding in a non-immune Fab-dependent manner. A distorted PpL-like fold is also seen in the C-terminal domain. As with PpL, Mub repeats were able to interact in vitro with a large repertoire of mammalian Igs, including secretory IgA. This hitherto undetected activity is consistent with the current model that antibody responses against commensal flora are of broad specificity and low affinity.
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==About this Structure==
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Crystal structure of a mucus-binding protein repeat reveals an unexpected functional immunoglobulin binding activity.,MacKenzie DA, Tailford LE, Hemmings AM, Juge N J Biol Chem. 2009 Nov 20;284(47):32444-53. Epub 2009 Sep 16. PMID:19758995<ref>PMID:19758995</ref>
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[[3i57]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lactobacillus_reuteri Lactobacillus reuteri]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I57 OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<ref group="xtra">PMID:019758995</ref><references group="xtra"/>
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</div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Lactobacillus reuteri]]
[[Category: Lactobacillus reuteri]]
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[[Category: Hemmings, A M.]]
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[[Category: Hemmings, A M]]
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[[Category: Juge, N.]]
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[[Category: Juge, N]]
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[[Category: MacKenzie, D A.]]
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[[Category: MacKenzie, D A]]
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[[Category: Tailford, L E.]]
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[[Category: Tailford, L E]]
[[Category: Beta grasp fold]]
[[Category: Beta grasp fold]]
[[Category: Cell wall]]
[[Category: Cell wall]]
[[Category: Peptidoglycan-anchor]]
[[Category: Peptidoglycan-anchor]]
[[Category: Protein binding]]
[[Category: Protein binding]]

Revision as of 06:20, 18 December 2014

Type 2 repeat of the mucus binding protein MUB from Lactobacillus reuteri

3i57, resolution 1.80Å

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