Growth factor receptor-bound proteins (GRB) are adaptor proteins. GRB2 links the epidermal growth factor receptor tyrosine kinase to the activation of Ras and its downstream kinases. GRB2 contains an SH2 domain which binds tyrosine phosphorylated sequences and 2 SH3 domains which direct complex formation of proline-rich sequences. GRB2 is involved in signal transduction. GRB7 interacts with EGFR and ephrin receptors and plays a role in itegrin signalling pathway. GRB10 interacts with insulin receptor and insulin-like growth factor receptors. GRBs contain SH2, Ras-associated (RA) and pleckstrin homology (PH) domains. For additional details on GRB10 see Grb10 SH2 Domain.
3D structures of Grb
Updated on 18-March-2013
GRB2
1ghu – hGRB2 SH2 domain (mutant) – human
1fhs, 1jyu, 2aoa, 2h46 - hGRB2 SH2 domain
2vvk, 2vwf, 2w0z - hGRB2 SH3 domain
1tze, 1bmb, 1bm2, 1zfp, 1qg1, 1jyq, 1jyr, 2aob, 2h5k, 2huw, 3c7i, 3imd, 3imj, 3in7, 3in8, 3kfj, 3n8m, 3n7y, 3n84, 3mxc, 3mxy, 3ov1, 3ove, 3s8n, 3s8o - hGRB2 SH2 domain + phosphotyrosyl peptide
1x0n - hGRB2 SH2 domain + inhibitor - NMR
1cj1 - hGRB2 SH2 domain + phosphotyrosyl derivative
1gbq, 2gbq, 3gbq, 4gbq, 1aze - GRB2 SH3 domain + SOS-1 peptide – NMR
1io6, 1h3h - GRB2 SH3 domain + ligand peptide – NMR
GRB7
1mw4, 2l4k – hGRB7 SH2 domain + receptor protein-tyrosine kinase ERBB-2 SH2 binding site – human – NMR
2qms – hGRB7 SH2 domain
3pqz – hGRB7 SH2 domain + cyclic peptide
1wgr – hGRB7 RA domain – NMR
GRB10
3hk0 – hGRB10 RA+PH domains
1nrv – hGRB10 SH2 domain
3m7f – hGRB10 SH2 domain + E3 ubiquitin-protein ligase NEDD4 C2 domain
