Growth factor receptor-bound protein

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===GRB2===
===GRB2===
-
[[1ghu]] – hGRB2 SH2 domain (mutant) – human<br />
+
[[1gri]], [[2h46]] – hGRB2 – human <br />
-
[[1fhs]], [[1jyu]], [[2aoa]], [[2h46]] - hGRB2 SH2 domain<br />
+
-
[[2vvk]], [[2vwf]], [[2w0z]] - hGRB2 SH3 domain<br />
+
-
[[1tze]], [[1bmb]], [[1bm2]], [[1zfp]], [[1qg1]], [[1jyq]], [[1jyr]], [[2aob]], [[2h5k]], [[2huw]], [[3c7i]], [[3imd]], [[3imj]], [[3in7]], [[3in8]], [[3kfj]], [[3n8m]], [[3n7y]], [[3n84]], [[3mxc]], [[3mxy]], [[3ov1]], [[3ove]], [[3s8n]], [[3s8o]] - hGRB2 SH2 domain + phosphotyrosyl peptide<br />
+
-
[[1x0n]] - hGRB2 SH2 domain + inhibitor - NMR<br />
+
-
[[1cj1]] - hGRB2 SH2 domain + phosphotyrosyl derivative<br />
+
-
[[1gbq]], [[2gbq]], [[3gbq]], [[4gbq]], [[1aze]] - GRB2 SH3 domain + SOS-1 peptide – NMR<br />
+
-
[[1io6]], [[1h3h]] - GRB2 SH3 domain + ligand peptide – NMR
+
-
===GRB7===
+
''GRB2 C terminal SH3 domain''
 +
 
 +
[[1gfc]], [[1gfd]] – hGRB2 C terminal SH3 domain - NMR<br />
 +
[[2vvk]], [[2vwf]], [[2w0z]] – hGRB2 C terminal SH3 domain <br />
 +
[[1io6]] – hGRB2 C terminal SH3 domain + ligand peptide - NMR<br />
 +
[[1gcq]] – hGRB2 C terminal SH3 domain + VAV proto-oncogene SH3 domain<br />
 +
 
 +
''GRB2 N terminal SH3 domain''
 +
 
 +
[[1gbr]], [[1gbq]], [[2gbq]], [[3gbq]], [[4gbq]] – mGRB2 N terminal SH3 domain + Sos-A peptide – mouse - NMR<br />
 +
[[1aze]] – mGRB2 N terminal SH3 domain + Sos-A peptide - NMR<br />
 +
 
 +
''GRB2 SH2 domain''
 +
 
 +
[[1jyu]] – hGRB2 SH2 domain <br />
 +
[[1ghu]] – hGRB2 SH2 domain (mutant) - NMR<br />
 +
[[1fhs]] – hGRB2 SH2 domain - NMR<br />
 +
[[1x0n]] – hGRB2 SH2 domain + inhibitor - NMR<br />
 +
[[2huw]] – hGRB2 SH2 domain + cyclopropane derivative<br />
 +
[[1cj1]] – hGRB2 SH2 domain + phosphor-Tyr derivative<br />
 +
[[2aoa]], [[2aob]] – hGRB2 SH2 domain + peptide mimetic<br />
 +
[[1tze]], [[1bmb]], [[1bm2]], [[1zfp]], [[1cj1]], [[1fyr]], [[1jyq]], [[1jyr]], [[2h5k]], [[3c7i]], [[3imd]], [[3imj]], [[3in7]], [[3in8]], [[3kfj]], [[3n8m]], [[3n7y]], [[3n84]], [[3mxc]], [[3mxy]], [[3ov1]], [[3ove]], [[3s8l]], [[3s8n]], [[3s8o]], [[1zfp]], [[1qg1]] – hGRB2 SH2 domain + phosphor-Tyr peptide<br />
 +
[[1qg1]] – hGRB2 SH2 domain + phosphor-Tyr peptide - NMR<br />
 +
 
 +
===GRB4===
 +
 
 +
[[4e6r]] – hGRB4 C terminal SH3 domain <br />
 +
 
 +
===GRB7===
-
[[1mw4]], [[2l4k]] – hGRB7 SH2 domain + receptor protein-tyrosine kinase ERBB-2 SH2 binding site – human – NMR<br />
 
[[2qms]] – hGRB7 SH2 domain <br />
[[2qms]] – hGRB7 SH2 domain <br />
-
[[3pqz]] – hGRB7 SH2 domain + cyclic peptide<br />
+
[[1mw4]] – hGRB7 SH2 domain + phosphor-Tyr peptide - NMR<br />
-
[[1wgr]] – hGRB7 RA domain – NMR<br />
+
[[2l4k]] – hGRB7 SH2 domain + phosphor-Tyr peptide - NMR<br />
 +
[[3pqz]] – hGRB7 SH2 domain + cyclic peptide <br />
 +
[[1wgr]] – hGRB7 RA domain - NMR<br />
-
===GRB10===
+
===GRB10===
-
[[3hk0]] – hGRB10 RA+PH domains <br />
 
[[1nrv]] – hGRB10 SH2 domain <br />
[[1nrv]] – hGRB10 SH2 domain <br />
-
[[3m7f]] – hGRB10 SH2 domain + E3 ubiquitin-protein ligase NEDD4 C2 domain<br />
+
[[3m7f]] – hGRB10 SH2 domain + NEDD4 C2 domain<br />
 +
[[3hk0]] – hGRB10 RA and PH domains <br />
 +
 
 +
===GRB14===
 +
 
 +
[[2aug]] – hGRB14 SH2 domain <br />
 +
[[2auh]] – hGRB14 BPS domain + insulin receptor kinase domain<br />
 +
 
 +
 
 +
 +
 
 +
 
 +
 

Revision as of 12:08, 30 April 2013

Structure of human Grb2 SH2 domain (pink) complex with phosphotyrosyl heptapeptide (gold) (PDB entry 1tze)

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman, Jaime Prilusky

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