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4bex
From Proteopedia
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| - | + | {{STRUCTURE_4bex| PDB=4bex | SCENE= }} | |
| + | ===Structure of human Cofilin1=== | ||
| - | + | ==Function== | |
| + | [[http://www.uniprot.org/uniprot/COF1_HUMAN COF1_HUMAN]] Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity. Regulates actin cytoskeleton dynamics. Important for normal progress through mitosis and normal cytokinesis. Plays a role in the regulation of cell morphology and cytoskeletal organization.<ref>PMID:15580268</ref> <ref>PMID:21834987</ref> | ||
| - | + | ==About this Structure== | |
| + | [[4bex]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BEX OCA]. | ||
| - | + | ==Reference== | |
| + | <references group="xtra"/><references/> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Gabrielsen, M.]] | ||
| + | [[Category: Klenjot, M.]] | ||
| + | [[Category: Kozielski, F.]] | ||
| + | [[Category: Mleczaka, A.]] | ||
| + | [[Category: Olson, M F.]] | ||
| + | [[Category: Pannifer, A.]] | ||
| + | [[Category: Talapatra, S.]] | ||
| + | [[Category: Wood, J.]] | ||
| + | [[Category: Actin-binding]] | ||
| + | [[Category: Cytoskeleton]] | ||
| + | [[Category: Structural protein]] | ||
Revision as of 07:35, 28 August 2013
Contents |
Structure of human Cofilin1
Function
[COF1_HUMAN] Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity. Regulates actin cytoskeleton dynamics. Important for normal progress through mitosis and normal cytokinesis. Plays a role in the regulation of cell morphology and cytoskeletal organization.[1] [2]
About this Structure
4bex is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- ↑ Gohla A, Birkenfeld J, Bokoch GM. Chronophin, a novel HAD-type serine protein phosphatase, regulates cofilin-dependent actin dynamics. Nat Cell Biol. 2005 Jan;7(1):21-9. Epub 2004 Dec 5. PMID:15580268 doi:10.1038/ncb1201
- ↑ Bai SW, Herrera-Abreu MT, Rohn JL, Racine V, Tajadura V, Suryavanshi N, Bechtel S, Wiemann S, Baum B, Ridley AJ. Identification and characterization of a set of conserved and new regulators of cytoskeletal organization, cell morphology and migration. BMC Biol. 2011 Aug 11;9:54. doi: 10.1186/1741-7007-9-54. PMID:21834987 doi:10.1186/1741-7007-9-54
