4bey

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m (Protected "4bey" [edit=sysop:move=sysop])
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'''Unreleased structure'''
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{{STRUCTURE_4bey| PDB=4bey | SCENE= }}
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===Night blindness causing G90D rhodopsin in complex with GaCT2 peptide===
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{{ABSTRACT_PUBMED_23579341}}
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The entry 4bey is ON HOLD
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==Function==
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[[http://www.uniprot.org/uniprot/OPSD_BOVIN OPSD_BOVIN]] Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth. Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change leading to G-protein activation and release of all-trans retinal (By similarity).<ref>PMID:16908857</ref> <ref>PMID:17060607</ref> [[http://www.uniprot.org/uniprot/GNAT1_BOVIN GNAT1_BOVIN]] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Transducin is an amplifier and one of the transducers of a visual impulse that performs the coupling between rhodopsin and cGMP-phosphodiesterase.
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Authors: Singhal, A., Ostermaier, M.K., Vishnivetskiy, S.A., Panneels, V., Homan, K.T., Tesmer, J.J.G., Veprintsev, D., Deupi, X., Gurevich, V.V., Schertler, G.F.X., Standfuss, J.
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==About this Structure==
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[[4bey]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BEY OCA].
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Description: Night blindness causing G90D rhodopsin in complex with GaCT2 peptide
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Bos taurus]]
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[[Category: Deupi, X.]]
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[[Category: Gurevich, V V.]]
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[[Category: Homan, K T.]]
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[[Category: Ostermaier, M K.]]
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[[Category: Panneels, V.]]
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[[Category: Schertler, G F.X.]]
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[[Category: Singhal, A.]]
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[[Category: Standfuss, J.]]
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[[Category: Tesmer, J J.G.]]
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[[Category: Veprintsev, D.]]
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[[Category: Vishnivetskiy, S A.]]
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[[Category: Active state]]
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[[Category: Congential stationary night blindness]]
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[[Category: Disease mutant]]
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[[Category: Gpcr]]
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[[Category: Membrane protein]]

Revision as of 07:44, 8 May 2013

Template:STRUCTURE 4bey

Contents

Night blindness causing G90D rhodopsin in complex with GaCT2 peptide

Template:ABSTRACT PUBMED 23579341

Function

[OPSD_BOVIN] Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth. Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change leading to G-protein activation and release of all-trans retinal (By similarity).[1] [2] [GNAT1_BOVIN] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Transducin is an amplifier and one of the transducers of a visual impulse that performs the coupling between rhodopsin and cGMP-phosphodiesterase.

About this Structure

4bey is a 2 chain structure with sequence from Bos taurus. Full crystallographic information is available from OCA.

Reference

  1. ↑ Nakamichi H, Okada T. Local peptide movement in the photoreaction intermediate of rhodopsin. Proc Natl Acad Sci U S A. 2006 Aug 22;103(34):12729-34. Epub 2006 Aug 14. PMID:16908857
  2. ↑ Salom D, Lodowski DT, Stenkamp RE, Le Trong I, Golczak M, Jastrzebska B, Harris T, Ballesteros JA, Palczewski K. Crystal structure of a photoactivated deprotonated intermediate of rhodopsin. Proc Natl Acad Sci U S A. 2006 Oct 31;103(44):16123-8. Epub 2006 Oct 23. PMID:17060607

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