4hsi

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'''Unreleased structure'''
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{{STRUCTURE_4hsi| PDB=4hsi | SCENE= }}
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===Glycoprotein B from Herpes simplex virus type 1, A504P/R505G/Q507G/N511G mutant, low-pH===
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{{ABSTRACT_PUBMED_23500487}}
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The entry 4hsi is ON HOLD until Mar 21 2014
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==Function==
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[[http://www.uniprot.org/uniprot/GB_HHV1K GB_HHV1K]] Envelope glycoprotein that forms spikes at the surface of virion envelope. Essential for the initial attachment to heparan sulfate moities of the host cell surface proteoglycans. Involved in fusion of viral and cellular membranes leading to virus entry into the host cell. Following initial binding of gD to one of its receptors, membrane fusion is mediated by the fusion machinery composed at least of gB and the heterodimer gH/gL. May also be involved in the fusion between the virion envelope and the outer nuclear membrane during virion egress. Also plays a role, together with gK, in virus-induced cell-to-cell fusion (syncytia formation).<ref>PMID:17299053</ref>
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Authors: Heldwein, E.E.
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==About this Structure==
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[[4hsi]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_herpesvirus_1_strain_kos Human herpesvirus 1 strain kos]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HSI OCA].
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Description: Glycoprotein B from Herpes simplex virus type 1, A504P/R505G/Q507G/N511G mutant, low-pH
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Human herpesvirus 1 strain kos]]
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[[Category: Heldwein, E E.]]
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[[Category: Viral envelope]]
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[[Category: Viral fusion protein]]
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[[Category: Viral protein]]

Revision as of 08:42, 27 March 2013

Template:STRUCTURE 4hsi

Contents

Glycoprotein B from Herpes simplex virus type 1, A504P/R505G/Q507G/N511G mutant, low-pH

Template:ABSTRACT PUBMED 23500487

Function

[GB_HHV1K] Envelope glycoprotein that forms spikes at the surface of virion envelope. Essential for the initial attachment to heparan sulfate moities of the host cell surface proteoglycans. Involved in fusion of viral and cellular membranes leading to virus entry into the host cell. Following initial binding of gD to one of its receptors, membrane fusion is mediated by the fusion machinery composed at least of gB and the heterodimer gH/gL. May also be involved in the fusion between the virion envelope and the outer nuclear membrane during virion egress. Also plays a role, together with gK, in virus-induced cell-to-cell fusion (syncytia formation).[1]

About this Structure

4hsi is a 4 chain structure with sequence from Human herpesvirus 1 strain kos. Full crystallographic information is available from OCA.

Reference

  1. ↑ Subramanian RP, Geraghty RJ. Herpes simplex virus type 1 mediates fusion through a hemifusion intermediate by sequential activity of glycoproteins D, H, L, and B. Proc Natl Acad Sci U S A. 2007 Feb 20;104(8):2903-8. Epub 2007 Feb 13. PMID:17299053 doi:10.1073/pnas.0608374104

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