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4ht1

From Proteopedia

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'''Unreleased structure'''
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{{STRUCTURE_4ht1| PDB=4ht1 | SCENE= }}
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===Human TWEAK in complex with the Fab fragment of a neutralizing antibody===
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{{ABSTRACT_PUBMED_23667509}}
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The entry 4ht1 is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/TNF12_HUMAN TNF12_HUMAN]] Binds to FN14 and possibly also to TNRFSF12/APO3. Weak inducer of apoptosis in some cell types. Mediates NF-kappa-B activation. Promotes angiogenesis and the proliferation of endothelial cells. Also involved in induction of inflammatory cytokines.<ref>PMID:10085077</ref>
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Authors: Lammens, A.
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==About this Structure==
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[[4ht1]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HT1 OCA].
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Description: Human TWEAK in complex with the Fab fragment of a neutralizing antibody
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==Reference==
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<ref group="xtra">PMID:023667509</ref><references group="xtra"/><references/>
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[[Category: Homo sapiens]]
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[[Category: Oryctolagus cuniculus]]
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[[Category: Lammens, A.]]
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[[Category: Antibody fab]]
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[[Category: Cytokine]]
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[[Category: Extracellular thd domain]]
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[[Category: Immune system]]
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[[Category: Membrane bound]]
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[[Category: Tnf homology domain]]
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[[Category: Tweak receptor]]

Revision as of 15:37, 19 June 2013

Template:STRUCTURE 4ht1

Contents

Human TWEAK in complex with the Fab fragment of a neutralizing antibody

Template:ABSTRACT PUBMED 23667509

Function

[TNF12_HUMAN] Binds to FN14 and possibly also to TNRFSF12/APO3. Weak inducer of apoptosis in some cell types. Mediates NF-kappa-B activation. Promotes angiogenesis and the proliferation of endothelial cells. Also involved in induction of inflammatory cytokines.[1]

About this Structure

4ht1 is a 3 chain structure with sequence from Homo sapiens and Oryctolagus cuniculus. Full crystallographic information is available from OCA.

Reference

  • Lammens A, Baehner M, Kohnert U, Niewoehner J, von Proff L, Schraeml M, Lammens K, Hopfner KP. Crystal Structure of Human TWEAK in Complex with the Fab Fragment of a Neutralizing Antibody Reveals Insights into Receptor Binding. PLoS One. 2013 May 8;8(5):e62697. doi: 10.1371/journal.pone.0062697. Print 2013. PMID:23667509 doi:10.1371/journal.pone.0062697
  1. ↑ Lynch CN, Wang YC, Lund JK, Chen YW, Leal JA, Wiley SR. TWEAK induces angiogenesis and proliferation of endothelial cells. J Biol Chem. 1999 Mar 26;274(13):8455-9. PMID:10085077

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