4ia0

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
'''Unreleased structure'''
+
{{STRUCTURE_4ia0| PDB=4ia0 | SCENE= }}
 +
===Crystal structure of the PDE5A1 catalytic domain in complex with novel inhibitors===
 +
{{ABSTRACT_PUBMED_23867165}}
-
The entry 4ia0 is ON HOLD until Paper Publication
+
==Function==
 +
[[http://www.uniprot.org/uniprot/PDE5A_HUMAN PDE5A_HUMAN]] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP.
-
Authors: Ren, J., Chen, T.T., Xu, Y.C.
+
==About this Structure==
 +
[[4ia0]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IA0 OCA].
-
Description: Crystal structure of the PDE5A1 catalytic domain in complex with novel inhibitors
+
==Reference==
 +
<ref group="xtra">PMID:023867165</ref><references group="xtra"/><references/>
 +
[[Category: 3',5'-cyclic-GMP phosphodiesterase]]
 +
[[Category: Chen, T.]]
 +
[[Category: Ren, J.]]
 +
[[Category: Xu, Y.]]
 +
[[Category: Hydrolase]]
 +
[[Category: Hydrolase-hydrolase inhibitor complex]]

Revision as of 12:08, 1 January 2014

Template:STRUCTURE 4ia0

Contents

Crystal structure of the PDE5A1 catalytic domain in complex with novel inhibitors

Template:ABSTRACT PUBMED 23867165

Function

[PDE5A_HUMAN] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP.

About this Structure

4ia0 is a 1 chain structure. Full crystallographic information is available from OCA.

Reference

  • Gong X, Wang G, Ren J, Liu Z, Wang Z, Chen T, Yang X, Jiang X, Shen J, Jiang H, Aisa HA, Xu Y, Li J. Exploration of the 5-bromopyrimidin-4(3H)-ones as potent inhibitors of PDE5. Bioorg Med Chem Lett. 2013 Sep 1;23(17):4944-7. doi: 10.1016/j.bmcl.2013.06.062. , Epub 2013 Jun 29. PMID:23867165 doi:http://dx.doi.org/10.1016/j.bmcl.2013.06.062

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4ia0"
Personal tools