4jep

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'''Unreleased structure'''
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{{STRUCTURE_4jep| PDB=4jep | SCENE= }}
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===Crystal structure of Toxoplasma gondii nucleoside triphosphate diphosphohydrolase 1 (NTPDase1)===
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{{ABSTRACT_PUBMED_23526564}}
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The entry 4jep is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/NTP2_TOXGO NTP2_TOXGO]] May perform an important processing step in the conversion of high energy nucleotides prior to uptake by the parasite. NTPAse-II has a specific activity 4.5-fold lower than NTPAse-I in hydrolysis of ATP. The primary difference between these isozymes lies in their ability to hydrolyze nucleoside triphosphate versus diphosphate substrates. While NTPAse-II hydrolyzes ATP to ADP and ADP to AMP at almost the same rate, NTPAse-I hydrolyzes ADP to AMP at a much slower rate (0.7% of the rate for ATP).
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Authors: Krug, U., Totzauer, R., Strater, N.
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==About this Structure==
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[[4jep]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Toxoplasma_gondii Toxoplasma gondii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JEP OCA].
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Description: Crystal structure of Toxoplasma gondii nucleoside triphosphate diphosphohydrolase 1 (NTPDASE1)
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[[Category: Nucleoside-triphosphatase]]
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[[Category: Toxoplasma gondii]]
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[[Category: Krug, U.]]
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[[Category: Strater, N.]]
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[[Category: Totzauer, R.]]
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[[Category: Hydrolase]]
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[[Category: Phosphatase]]

Revision as of 22:50, 10 April 2013

Template:STRUCTURE 4jep

Crystal structure of Toxoplasma gondii nucleoside triphosphate diphosphohydrolase 1 (NTPDase1)

Template:ABSTRACT PUBMED 23526564

Function

[NTP2_TOXGO] May perform an important processing step in the conversion of high energy nucleotides prior to uptake by the parasite. NTPAse-II has a specific activity 4.5-fold lower than NTPAse-I in hydrolysis of ATP. The primary difference between these isozymes lies in their ability to hydrolyze nucleoside triphosphate versus diphosphate substrates. While NTPAse-II hydrolyzes ATP to ADP and ADP to AMP at almost the same rate, NTPAse-I hydrolyzes ADP to AMP at a much slower rate (0.7% of the rate for ATP).

About this Structure

4jep is a 2 chain structure with sequence from Toxoplasma gondii. Full crystallographic information is available from OCA.

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