2c41

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[[Image:2c41.gif|left|200px]]<br /><applet load="2c41" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:2c41.gif|left|200px]]
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caption="2c41, resolution 1.81&Aring;" />
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'''X-RAY STRUCTURE OF DPS FROM THERMOSYNECHOCOCCUS ELONGATUS'''<br />
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{{Structure
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|PDB= 2c41 |SIZE=350|CAPTION= <scene name='initialview01'>2c41</scene>, resolution 1.81&Aring;
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|SITE= <scene name='pdbsite=AC1:Cl+Binding+Site+For+Chain+B'>AC1</scene>
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|LIGAND= <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene> and <scene name='pdbligand=PGE:TRIETHYLENE GLYCOL'>PGE</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''X-RAY STRUCTURE OF DPS FROM THERMOSYNECHOCOCCUS ELONGATUS'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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2C41 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Thermosynechococcus_elongatus Thermosynechococcus elongatus] with <scene name='pdbligand=CL:'>CL</scene>, <scene name='pdbligand=PG4:'>PG4</scene> and <scene name='pdbligand=PGE:'>PGE</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Known structural/functional Site: <scene name='pdbsite=AC1:Cl+Binding+Site+For+Chain+B'>AC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C41 OCA].
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2C41 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Thermosynechococcus_elongatus Thermosynechococcus elongatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C41 OCA].
==Reference==
==Reference==
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Antioxidant Dps protein from the thermophilic cyanobacterium Thermosynechococcus elongatus., Franceschini S, Ceci P, Alaleona F, Chiancone E, Ilari A, FEBS J. 2006 Nov;273(21):4913-28. Epub 2006 Oct 3. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17018059 17018059]
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Antioxidant Dps protein from the thermophilic cyanobacterium Thermosynechococcus elongatus., Franceschini S, Ceci P, Alaleona F, Chiancone E, Ilari A, FEBS J. 2006 Nov;273(21):4913-28. Epub 2006 Oct 3. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17018059 17018059]
[[Category: Single protein]]
[[Category: Single protein]]
[[Category: Thermosynechococcus elongatus]]
[[Category: Thermosynechococcus elongatus]]
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[[Category: thermostable protein]]
[[Category: thermostable protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:44:46 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 16:10:31 2008''

Revision as of 14:10, 20 March 2008

Image:2c41.gif


PDB ID 2c41

Drag the structure with the mouse to rotate
, resolution 1.81Å
Sites:
Ligands: , and
Coordinates: save as pdb, mmCIF, xml



X-RAY STRUCTURE OF DPS FROM THERMOSYNECHOCOCCUS ELONGATUS


Overview

DNA-binding proteins from starved cells (Dps proteins) protect bacteria primarily from oxidative damage. They are composed of 12 identical subunits assembled with 23-symmetry to form a compact cage-like structure known to be stable at temperatures > 70 degrees C and over a wide pH range. Thermosynechococcus elongatus Dps thermostability is increased dramatically relative to mesophilic Dps proteins. Hydrophobic interactions at the dimeric and trimeric interfaces called Dps-like are replaced by salt bridges and hydrogen bonds, a common strategy in thermophiles. Moreover, the buried surface area at the least-extended Dps-like interface is significantly increased. A peculiarity of T. elongatus Dps is the presence of a chloride ion coordinated with threefold symmetry-related arginine residues lining the opening of the Dps-like pore toward the internal cavity. T. elongatus Dps conserves the unusual intersubunit ferroxidase centre that allows the Dps protein family to oxidize Fe(II) with hydrogen peroxide, thereby inhibiting free radical production via Fenton chemistry. This catalytic property is of special importance in T. elongatus (which lacks the catalase gene) in the protection of DNA and photosystems I and II from hydrogen peroxide-mediated oxidative damage.

About this Structure

2C41 is a Single protein structure of sequence from Thermosynechococcus elongatus. Full crystallographic information is available from OCA.

Reference

Antioxidant Dps protein from the thermophilic cyanobacterium Thermosynechococcus elongatus., Franceschini S, Ceci P, Alaleona F, Chiancone E, Ilari A, FEBS J. 2006 Nov;273(21):4913-28. Epub 2006 Oct 3. PMID:17018059

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