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| - | [[Image:2c5m.gif|left|200px]]<br /><applet load="2c5m" size="350" color="white" frame="true" align="right" spinBox="true" | + | #REDIRECT [[2vo1]] This PDB entry is obsolete and replaced by 2vo1 |
| - | caption="2c5m, resolution 2.8Å" />
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| - | '''CRYSTAL STRUCTURE OF THE SYNTHETASE DOMAIN OF HUMAN CTP SYNTHETASE'''<br />
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| - | ==Overview==
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| - | Cytidine triphosphate synthetase (CTPS) is a key enzyme in nucleic acid and phospholipid biosynthesis and its activity is increased in certain human cancers, making it a promising drug target. The crystal structure of the synthetase domain of human CTPS, which represents the first structure of a CTPS from an eukaryote, has been determined. The structure is homotetrameric and each active site is formed by three different subunits. Sulfate ions bound to the active sites indicate the positions of phosphate-binding sites for the substrates ATP and UTP and the feedback inhibitor CTP. Together with earlier structures of bacterial CTPS, the human CTPS structure provides an extended understanding of the structure-function relationship of CTPS-family members. The structure also serves as a basis for structure-based design of anti-proliferative inhibitors.
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| - | ==About this Structure==
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| - | 2C5M is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=SO4:'>SO4</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/CTP_synthase CTP synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.4.2 6.3.4.2] Known structural/functional Site: <scene name='pdbsite=AC1:So4+Binding+Site+For+Chain+A'>AC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C5M OCA].
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| - | ==Reference==
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| - | Structure of the synthetase domain of human CTP synthetase, a target for anticancer therapy., Kursula P, Flodin S, Ehn M, Hammarstrom M, Schuler H, Nordlund P, Stenmark P, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Jul 1;62(Pt, 7):613-7. Epub 2006 Jun 10. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16820675 16820675]
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| - | [[Category: CTP synthase]]
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| - | [[Category: Homo sapiens]]
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| - | [[Category: Single protein]]
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| - | [[Category: Arrowsmith, C.]]
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| - | [[Category: Berg, S Van Den.]]
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| - | [[Category: Berglund, H.]]
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| - | [[Category: Edwards, A.]]
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| - | [[Category: Ehn, M.]]
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| - | [[Category: Flodin, S.]]
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| - | [[Category: Graslund, S.]]
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| - | [[Category: Hallberg, B M.]]
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| - | [[Category: Hammarstrom, M.]]
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| - | [[Category: Kotenyova, T.]]
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| - | [[Category: Kursula, P.]]
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| - | [[Category: Nilsson-Ehle, P.]]
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| - | [[Category: Nordlund, P.]]
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| - | [[Category: Ogg, D.]]
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| - | [[Category: Persson, C.]]
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| - | [[Category: Sagemark, J.]]
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| - | [[Category: Schiavone, L Holmberg.]]
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| - | [[Category: Schuler, H.]]
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| - | [[Category: Stenmark, P.]]
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| - | [[Category: Sundstrom, M.]]
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| - | [[Category: Thorsell, A G.]]
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| - | [[Category: Weigelt, J.]]
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| - | [[Category: SO4]]
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| - | [[Category: amidotransferase]]
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| - | [[Category: ctp]]
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| - | [[Category: ctp synthase]]
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| - | [[Category: ctp synthetase]]
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| - | [[Category: ctps]]
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| - | [[Category: cytidine 5-prime triphosphate synthetase]]
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| - | [[Category: glutamine]]
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| - | [[Category: ligase]]
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| - | [[Category: phosphorylation]]
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| - | [[Category: pyrimidine biosynthesis]]
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| - | [[Category: utp]]
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| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:45:10 2008''
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