3fhc

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==About this Structure==
==About this Structure==
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[[3fhc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FHC OCA].
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[[3fhc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FHC OCA].
==See Also==
==See Also==
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==Reference==
==Reference==
<ref group="xtra">PMID:019219046</ref><references group="xtra"/><references/>
<ref group="xtra">PMID:019219046</ref><references group="xtra"/><references/>
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[[Category: Homo sapiens]]
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[[Category: Human]]
[[Category: Conti, E.]]
[[Category: Conti, E.]]
[[Category: Moeller, H von.]]
[[Category: Moeller, H von.]]

Revision as of 07:27, 5 February 2014

Template:STRUCTURE 3fhc

Contents

Crystal structure of human Dbp5 in complex with Nup214

Template:ABSTRACT PUBMED 19219046

Disease

[NU214_HUMAN] Note=A chromosomal aberration involving NUP214 is found in a subset of acute myeloid leukemia (AML); also known as acute non-lymphocytic leukemia. Translocation t(6;9)(p23;q34) with DEK. It results in the formation of a DEK-CAN fusion gene. Note=A chromosomal aberration involving NUP214 is found in some cases of acute undifferentiated leukemia (AUL). Translocation t(6;9)(q21;q34.1) with SET.

Function

[NU214_HUMAN] May serve as a docking site in the receptor-mediated import of substrates across the nuclear pore complex. [DD19B_HUMAN] ATP-dependent RNA helicase involved in mRNA export from the nucleus. Rather than unwinding RNA duplexes, DDX19B functions as a remodeler of ribonucleoprotein particles, whereby proteins bound to nuclear mRNA are dissociated and replaced by cytoplasmic mRNA binding proteins.

About this Structure

3fhc is a 2 chain structure with sequence from Human. Full crystallographic information is available from OCA.

See Also

Reference

  • von Moeller H, Basquin C, Conti E. The mRNA export protein DBP5 binds RNA and the cytoplasmic nucleoporin NUP214 in a mutually exclusive manner. Nat Struct Mol Biol. 2009 Feb 15. PMID:19219046 doi:nsmb.1561

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