2cp9

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{{STRUCTURE_2cp9| PDB=2cp9 | SCENE= }}
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==Solution structure of RSGI RUH-042, a UBA domain from human mitochondrial elongation factor Ts==
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===Solution structure of RSGI RUH-042, a UBA domain from human mitochondrial elongation factor Ts===
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<StructureSection load='2cp9' size='340' side='right' caption='[[2cp9]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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== Structural highlights ==
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==Disease==
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<table><tr><td colspan='2'>[[2cp9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CP9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CP9 FirstGlance]. <br>
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[[http://www.uniprot.org/uniprot/EFTS_HUMAN EFTS_HUMAN]] Defects in TSFM are the cause of combined oxidative phosphorylation deficiency type 3 (COXPD3) [MIM:[http://omim.org/entry/610505 610505]]. Defects in the mitochondrial oxidative phosphorylation system result in devastating, mainly multisystem, diseases. COXPD3 symptoms include severe metabolic acidosis with encephalomyopathy or with hypertrophic cardiomyopathy. Patients show a severe defect in mitochondrial translation leading to a failure to assemble adequate amounts of three of the oxidative phosphorylation complexes.<ref>PMID:17033963</ref>
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</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cp9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cp9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2cp9 RCSB], [http://www.ebi.ac.uk/pdbsum/2cp9 PDBsum], [http://www.topsan.org/Proteins/RSGI/2cp9 TOPSAN]</span></td></tr>
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<table>
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==Function==
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== Disease ==
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[[http://www.uniprot.org/uniprot/EFTS_HUMAN EFTS_HUMAN]] Defects in TSFM are the cause of combined oxidative phosphorylation deficiency type 3 (COXPD3) [MIM:[http://omim.org/entry/610505 610505]]. Defects in the mitochondrial oxidative phosphorylation system result in devastating, mainly multisystem, diseases. COXPD3 symptoms include severe metabolic acidosis with encephalomyopathy or with hypertrophic cardiomyopathy. Patients show a severe defect in mitochondrial translation leading to a failure to assemble adequate amounts of three of the oxidative phosphorylation complexes.<ref>PMID:17033963</ref>
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== Function ==
[[http://www.uniprot.org/uniprot/EFTS_HUMAN EFTS_HUMAN]] Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity).[HAMAP-Rule:MF_03135]
[[http://www.uniprot.org/uniprot/EFTS_HUMAN EFTS_HUMAN]] Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity).[HAMAP-Rule:MF_03135]
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== Evolutionary Conservation ==
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==About this Structure==
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[[Image:Consurf_key_small.gif|200px|right]]
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[[2cp9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CP9 OCA].
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cp/2cp9_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
*[[Elongation factor|Elongation factor]]
*[[Elongation factor|Elongation factor]]
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== References ==
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==Reference==
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<references/>
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<references group="xtra"/><references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Hirota, H.]]
[[Category: Hirota, H.]]

Revision as of 02:15, 30 September 2014

Solution structure of RSGI RUH-042, a UBA domain from human mitochondrial elongation factor Ts

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