2xvq

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{{STRUCTURE_2xvq| PDB=2xvq | SCENE= }}
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==HUMAN SERUM ALBUMIN COMPLEXED WITH DANSYL-L-SARCOSINE==
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===HUMAN SERUM ALBUMIN COMPLEXED WITH DANSYL-L-SARCOSINE===
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<StructureSection load='2xvq' size='340' side='right' caption='[[2xvq]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
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{{ABSTRACT_PUBMED_20940056}}
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2xvq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XVQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XVQ FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=9DS:DANSYL-L-SARCOSINE'>9DS</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2bxq|2bxq]], [[1hk4|1hk4]], [[2bxi|2bxi]], [[2vuf|2vuf]], [[1o9x|1o9x]], [[1bke|1bke]], [[2bxk|2bxk]], [[1hk1|1hk1]], [[1uor|1uor]], [[1e7b|1e7b]], [[1h9z|1h9z]], [[1hk2|1hk2]], [[2esg|2esg]], [[1hk5|1hk5]], [[1e7e|1e7e]], [[2bxg|2bxg]], [[2bxh|2bxh]], [[2bxo|2bxo]], [[2bxf|2bxf]], [[1ysx|1ysx]], [[1e7g|1e7g]], [[1tf0|1tf0]], [[2bxn|2bxn]], [[2bxe|2bxe]], [[2bxc|2bxc]], [[1ao6|1ao6]], [[1e7c|1e7c]], [[1gnj|1gnj]], [[1e7h|1e7h]], [[2bxa|2bxa]], [[1hk3|1hk3]], [[2bxb|2bxb]], [[1e7i|1e7i]], [[2bxl|2bxl]], [[1gni|1gni]], [[1ha2|1ha2]], [[1bj5|1bj5]], [[1e7a|1e7a]], [[2bxp|2bxp]], [[2bxd|2bxd]], [[1e78|1e78]], [[1bm0|1bm0]], [[2vdb|2vdb]], [[1e7f|1e7f]], [[1n5u|1n5u]], [[2bx8|2bx8]], [[2bxm|2bxm]], [[2vue|2vue]], [[2xvw|2xvw]], [[2xvu|2xvu]], [[2xvv|2xvv]], [[2xw0|2xw0]], [[2xsi|2xsi]], [[2xw1|2xw1]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xvq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xvq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xvq RCSB], [http://www.ebi.ac.uk/pdbsum/2xvq PDBsum]</span></td></tr>
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</table>
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== Disease ==
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[[http://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN]] Defects in ALB are a cause of familial dysalbuminemic hyperthyroxinemia (FDH) [MIM:[http://omim.org/entry/103600 103600]]. FDH is a form of euthyroid hyperthyroxinemia that is due to increased affinity of ALB for T(4). It is the most common cause of inherited euthyroid hyperthyroxinemia in Caucasian population.<ref>PMID:8048949</ref> <ref>PMID:7852505</ref> <ref>PMID:9329347</ref> <ref>PMID:9589637</ref>
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== Function ==
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[[http://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN]] Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.<ref>PMID:19021548</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Human serum albumin (HSA) has two primary binding sites for drug molecules. These sites selectively bind different dansylated amino acid compounds, which-due to their intrinsic fluorescence-have long been used as specific markers for the drug pockets on HSA. We present here the co-crystal structures of HSA in complex with six dansylated amino acids that are specific for either drug site 1 (dansyl-l-asparagine, dansyl-l-arginine, dansyl-l-glutamate) or drug site 2 (dansyl-l-norvaline, dansyl-l-phenylalanine, dansyl-l-sarcosine). Our results explain the structural basis of the site-specificity of different dansylated amino acids. They also show that fatty acid binding has only a modest effect on binding of dansylated amino acids to drug site 1 and identify the location of secondary binding sites.
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==Disease==
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Structural basis of binding of fluorescent, site-specific dansylated amino acids to human serum albumin.,Ryan AJ, Ghuman J, Zunszain PA, Chung CW, Curry S J Struct Biol. 2010 Oct 18. PMID:20940056<ref>PMID:20940056</ref>
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[[http://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN]] Defects in ALB are a cause of familial dysalbuminemic hyperthyroxinemia (FDH) [MIM:[http://omim.org/entry/103600 103600]]. FDH is a form of euthyroid hyperthyroxinemia that is due to increased affinity of ALB for T(4). It is the most common cause of inherited euthyroid hyperthyroxinemia in Caucasian population.<ref>PMID:8048949</ref><ref>PMID:7852505</ref><ref>PMID:9329347</ref><ref>PMID:9589637</ref>
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==Function==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[http://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN]] Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.<ref>PMID:19021548</ref>
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</div>
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==About this Structure==
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[[2xvq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XVQ OCA].
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==See Also==
==See Also==
*[[Albumin|Albumin]]
*[[Albumin|Albumin]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:020940056</ref><references group="xtra"/><references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Curry, S.]]
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[[Category: Curry, S]]
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[[Category: Ryan, A J.]]
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[[Category: Ryan, A J]]
[[Category: Transport protein]]
[[Category: Transport protein]]

Revision as of 13:37, 18 December 2014

HUMAN SERUM ALBUMIN COMPLEXED WITH DANSYL-L-SARCOSINE

2xvq, resolution 2.90Å

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